ReviewSleep science (Sao Paulo, Brazil)
The hypothalamic-pituitary-adrenal axis and the central monoaminergic systems: a pathophysiological link to insomnia with clinical implications.
Review in Sleep science (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- A comparison between rTMS and antidepressant medication on depressive symptom clusters in treatment-resistant depression.European archives of psychiatry and clinical neuroscience · 2025Trial
- Prevalence, Severity, Concomitant Factors, and Natural Trajectory of Insomnia in Patients with Long COVID.Journal of clinical medicine · 2025Article
- Study on the correlation between insomnia degree and quality of life in psychiatric outpatients in Chifeng city.World journal of psychiatry · 2025Article
- The mediating role of rumination between fear of disease progression and sleep disturbance in melanoma patients: a dual-perspective analysis based on person-centered and variable-centered approaches.Frontiers in public health · 2025Article
- Efficacy and underlying mechanisms of three-circle post standing qigong on insomnia in college students: a four-arm, double-blind, randomized controlled trial protocol.BMC complementary medicine and therapies · 2024Article
- Sleep traits and risk of end-stage renal disease: a mendelian randomization study.BMC medical genomics · 2023Article
- Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital.Infection and drug resistance · 2023Article
- Association of Atrial Fibrillation with Insomnia in the Elderly Population.Journal of primary care & community healthArticle
- HD-tDCS over prefrontal cortex alleviates the inhibitory control and sleep problems of insomnia with objective short sleep duration.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors present a theoretical overview of the hypothalamic-pituitary-adrenal axis and the central monoaminergic systems, focusing on a putative pathophysiological relationship to insomnia complaints. Insomnia is an independent and self-perpetuating disorder that requires diagnostic and therapeutic attention in the presence of concomitant disorders, likely with bidirectional influence. An adequate understanding of such mechanisms can help for a better understanding of the interplay between clinical features, neurotransmitters, and the adrenal hypothalamic-pituitary axis may help clinicians to better manage insomnia patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.