Evidence map›Paper›PMID 35662702›Full record

ArticleFrontiers in pharmacology2022

NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species.

Anantha Harijith, Prathima Basa, Alison Ha, Jaya Thomas, Anjum Jafri, Panfeng Fu, Peter M MacFarlane, Thomas M Raffay, Viswanathan Natarajan, Tara Sudhadevi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms Underlying Altitude-Induced and Group 3 Pulmonary Hypertension.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Sorting nexin 10 knockdown: new strategies for alleviating sepsis-associated acute lung injury.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Insights into Manganese Superoxide Dismutase and Human Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anantha HarijithDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Prathima BasaDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Alison HaDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Jaya ThomasDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Anjum JafriDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Panfeng FuDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Peter M MacFarlaneDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Thomas M RaffayDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Viswanathan NatarajanDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Tara SudhadeviDepartment of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USUniversity of Illinois Chicago · US

Funding

Role of novel SphK1 inhibitor, PF543 in therapy of Bronchopulmonary dysplasia and Airway remodelingR01HD090887 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HARIJITH, ANANTHA · 2018 to 2022
$1.5M
NICHD NIH HHS R01 HD090887
6 · The paper itself

Abstract

Management of acute respiratory distress involves O

Indexed as

alveolar type 2 epithelial cellapoptosishyperoxic acute lung injurymitochondrial ROSNADPH oxidase 4

Identifiers

PMID35662702
PMCPMC9160661
OpenAlexW4280620672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.