Evidence map›Paper›PMID 35662543›Full record

ArticleJournal of pharmaceutical sciences2022

Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and Intravitreal).

Deeksha Jakka, Anusha V Matadh, Vijay Kumar Shankar, H N Shivakumar, S Narasimha Murthy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  5. Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Deeksha JakkaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, USA.
Anusha V MatadhInstitute for Drug Delivery and Biomedical Research, Bengaluru 560086, India.
Vijay Kumar ShankarDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, USA.
H N ShivakumarInstitute for Drug Delivery and Biomedical Research, Bengaluru 560086, India; KLE College of Pharmacy, Bengaluru, 560010, India.
S Narasimha MurthyInstitute for Drug Delivery and Biomedical Research, Bengaluru 560086, India; Topical Products Testing LLC, Oxford, MS 38655, USA. Electronic address: murthygroup@gmail.com.
University of Mississippi · USKLE University · INTopricin (United States) · US

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Microneedles are used to deliver drugs topically across the skin and mucous membranes. Dissolvable microneedles are made using soluble polymers, which disintegrates in the tissue and release the entire payload instantaneously including the polymer construct. Often, a slow release of drug into the tissue is desirable to overcome the severity of side effects at the site of administration as well as systemic adverse effects. In addition, controlled release of active pharmaceutical ingredient (API) only (not the excipients) is safe and effective particularly when the drug delivery is intended to sensitive organs like the eye. In this project, the feasibility of fabricating polymer coated polymeric (PCP) microneedles to achieve a gradual release of only the active ingredient from the device was investigated. The potential application of such PCP microneedles in the dermal and intravitreal drug delivery was also explored using animal tissue models. The PCP microneedles were found to be intact even after prolonged contact with the release medium. The time at which 50% (T50%) of dextran (10 K) was released in case of microneedles prepared using 20% of core polymer (PVP-K30) was about 15 min versus less than 5 min in the case of uncoated microneedles. Whereas when the core polymer concentration was increased to 50%, the T

Indexed as

ExcipientsPolymersAdministration, CutaneousAnimalsDelayed-Action PreparationsDextransDrug Delivery SystemsLidocaineMicroinjectionsNeedlesSkinVoriconazoleDelayed-Action PreparationsDextransExcipientsLidocainePolymersVoriconazoleCoatingDermalDextranDrug deliveryEthyl celluloseLidocaineMicroneedlesOcularPVPVitreous humorVoriconazole

Identifiers

PMID35662543
PMCPMC10775835
OpenAlexW4282915429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.