ArticleJournal of experimental botany2022
Altered collective mitochondrial dynamics in the Arabidopsis msh1 mutant compromising organelle DNA maintenance.
Article in Journal of experimental botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation.bioRxiv : the preprint server for biology · 2026Article
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance.The Plant journal : for cell and molecular biology · 2026Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell.Biophysical journal · 2026Article
- Expansion of the MutS gene family in plants.The Plant cell · 2025Article
- Asymmetric partitioning of persistent paternal mitochondria during cell divisions safeguards embryo development and mitochondrial inheritance.Developmental cell · 2025Article
- Cytoplasmic inheritance: The transmission of plastid and mitochondrial genomes across cells and generations.Plant physiology · 2025Review
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Expansion of the MutS Gene Family in Plants.bioRxiv : the preprint server for biology · 2024Article
- Stromule Geometry Allows Optimal Spatial Regulation of Organelle Interactions in the Quasi-2D Cytoplasm.Plant & cell physiology · 2024Article
- Genome copy number predicts extreme evolutionary rate variation in plant mitochondrial DNA.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Stochastic organelle genome segregation through Arabidopsis development and reproduction.The New phytologist · 2024Article
- Variable-Angle Epifluorescence Microscopy for Single-Particle Tracking in the Plant ER.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Social networks in the single cell.Journal of experimental botany · 2022Article
- Sorting of mitochondrial and plastid heteroplasmy inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Exchange on dynamic encounter networks allows plant mitochondria to collect complete sets of mitochondrial DNA products despite their incomplete genomes.Quantitative plant biology · 2022Article
- (ID-ICPMB05) Running on Empty: Mitochondria Without DNA Exhibit Differential Motility and Connectivity.Physiologia plantarumArticle
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4 authors at 2 institutions in 2 countries.
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Abstract
Mitochondria form highly dynamic populations in the cells of plants (and almost all eukaryotes). The characteristics and benefits of this collective behaviour, and how it is influenced by nuclear features, remain to be fully elucidated. Here, we use a recently developed quantitative approach to reveal and analyse the physical and collective 'social' dynamics of mitochondria in an Arabidopsis msh1 mutant where the organelle DNA maintenance machinery is compromised. We use a newly created line combining the msh1 mutant with mitochondrially targeted green fluorescent protein (GFP), and characterize mitochondrial dynamics with a combination of single-cell time-lapse microscopy, computational tracking, and network analysis. The collective physical behaviour of msh1 mitochondria is altered from that of the wild type in several ways: mitochondria become less evenly spread, and networks of inter-mitochondrial encounters become more connected, with greater potential efficiency for inter-organelle exchange-reflecting a potential compensatory mechanism for the genetic challenge to the mitochondrial DNA population, supporting more inter-organelle exchange. We find that these changes are similar to those observed in friendly, where mitochondrial dynamics are altered by a physical perturbation, suggesting that this shift to higher connectivity may reflect a general response to mitochondrial challenges, where physical dynamics of mitochondria may be altered to control the genetic structure of the mtDNA population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.