ArticleScientific reports2022
Structural retinal changes in cerebral small vessel disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Characteristics of Study Design and Statistical Analysis in OCT-Based Studies of Neurodegeneration.Ophthalmology science · 2026Article
- [Neurodegeneration and retinal changes-A literature overview].Zeitschrift fur Gerontologie und Geriatrie · 2025Review
- Attitudes towards telemedicine in ophthalmology: a population-based online survey in Germany.BMC health services research · 2025Article
- Retinal imaging and tissue analysis for frontotemporal degeneration: recent advances and challenges for biomarker development.Journal of neurology, neurosurgery, and psychiatry · 2025Review
- Structure-Function Associations Between Quantitative Contrast Sensitivity Function And Peripapillary Optical Coherence Tomography Angiography in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Predicting cardiovascular disease risk using retinal optical coherence tomography imaging.Frontiers in artificial intelligence · 2025Article
- Eye-brain connections revealed by multimodal retinal and brain imaging genetics.Nature communications · 2024Article
- The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.Quantitative imaging in medicine and surgery · 2024Article
- Retinal structure and vessel density changes in cerebral small vessel disease.Frontiers in neuroscience · 2024Article
- Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank.medRxiv : the preprint server for health sciences · 2023Article
- Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field.Frontiers in aging neuroscience · 2023Review
- Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population.International journal of ophthalmology · 2023Article
- Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S.Frontiers in neurology · 2022Article
- Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral small vessel disease (CSVD) is an important contributor to cognitive impairment and stroke. Previous research has suggested associations with alterations in single retinal layers. We have assessed changes of all individual retinal layers in CSVD using high-resolution optical coherence tomography (OCT) for the first time. Subjects with recent magnetic resonance imaging (MRI) underwent macular and peripapillary retinal imaging using OCT for this case-control study. Number and volume ratio index (WMRI) of white matter lesions (WML) were determined on MRI. Data were analyzed using multiple linear regression models. 27 CSVD patients and 9 control participants were included. Ganglion cell layer (GCL) volume was significantly reduced in patients with CSVD compared to age-matched controls (p = 0.008). In patients with CSVD, larger foveal outer plexiform layer (OPL) volume and decreased temporal peripapillary retinal nerve fiber layer (RNFL) thickness were significantly associated with a higher WMRI in linear regression when controlling for age (p ≤ 0.033). Decreased foveal GCL volume and temporal-inferior RNFL thickness at Bruch's membrane opening (MRW), and increased temporal MRW were associated with a higher WML burden (p ≤ 0.037). Thus, we identified alterations in several OCT layers in individuals with CSVD (GCL, OPL, MRW and RNFL). Their potential diagnostic value merits further study.
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