ArticleThe Indian journal of medical research2021
Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction.
Article in The Indian journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Cellular and molecular mechanisms of nasolacrimal duct obstruction: New insights into CD4Journal of advanced research · 2026Article
- Distinct Tear Element Signatures in Primary Acquired Nasolacrimal Duct Obstruction Identified by Particle-Induced X-Ray Emission.Investigative ophthalmology & visual science · 2026Article
- Proteome Analysis of Nasolacrimal Duct Lavage Fluid in Patients with Primary Acquired Nasolacrimal Duct Obstruction.International journal of molecular sciences · 2026Article
- Tear Proteome Analysis with Patients with Primary Nasolacrimal Duct Obstruction.International journal of molecular sciences · 2025Article
- Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model.Investigative ophthalmology & visual science · 2025Article
- Evaluating failed dacryocystorhinostomy using computed tomography dacryocystography: a preliminary analysis of bony ostium characteristics in an Asian population.Quantitative imaging in medicine and surgery · 2025Article
- A preliminary study on the clinical characteristics of lacrimal duct obstruction in patients with a history of anterior uveitis.Frontiers in medicine · 2025Article
- Anatomic characteristics of the lacrimal sac and adjacent bony structures-a computed tomographic-dacryocystography research.International journal of ophthalmology · 2025Article
- Bibliometric and visualized analysis of research hotpots and future prospects in lacrimal duct obstruction disease (1900 to 2024).International journal of ophthalmology · 2025Article
- Inflammatory cytokines in tears of patients with lacrimal duct obstruction.The Indian journal of medical research · 2023Article
- Authors' response.The Indian journal of medical research · 2023Article
- Type 1-type 2 interferon imbalance in dry eye disease.Indian journal of ophthalmology · 2023Observational
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & objectives: Tear proteomic changes can be a candidate etiopathogenesis of lacrimal duct obstruction diseases (LDODs). Studies on proteomics have focused primarily on nasolacrimal duct obstruction, and some specific inflammatory cytokines such as interferon (IFN)-α2a, interleukin (IL)-8 and IL-10, have not been investigated. In addition, differences in inflammatory cytokines in tears according to the LDOD subtype have not been reported. This study aimed to quantitatively compare inflammatory cytokines in tears from patients with LDOD and investigate tear-cytokine differences among different LDOD subtypes. Methods: Tear samples were collected from both eyes of 30 patients with unilateral LDOD: five patients with prelacrimal obstruction, five with acute dacryocystitis and 20 with chronic dacryocystitis. The contralateral eyes were used as controls. IFN-α2a, IFN-β, IFN-γ, IL-17A, IL-6, IL-8, tumour necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF)-A, induced protein-10 (IP-10) and monocyte chemotactic protein-1 (MCP-1) were quantified in all samples. Results: The expression of eight cytokines (except for IP-10 and MCP-1) were significantly increased in the affected eyes compared with those in the control eyes. The levels of nine inflammatory cytokines (except for IP-10) in the affected eyes of patients with chronic dacryocystitis were higher than those in the affected eyes of patients with prelacrimal obstruction. In addition, patients with chronic dacryocystitis presented significantly higher IFN-γ level than those with prelacrimal obstruction or acute dacryocystitis. Interpretation & conclusions: Specific pro-inflammatory cytokines were increased in tears of patients with LDOD compared with those in the controls. The specific cytokine profiles observed in the tears of individuals with different LDOD subtypes may be associated with the unique aetiopathogenesis of these conditions.
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