Evidence map›Paper›PMID 35661987›Full record

ReviewHormones (Athens, Greece)2022

Non-invasive diagnosis and staging of non-alcoholic fatty liver disease.

Stergios Kechagias, Mattias Ekstedt, Christian Simonsson, Patrik Nasr

Open access · hybridAbstract readReview
In one paragraph

Review in Hormones (Athens, Greece), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stergios KechagiasDepartment of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden. stergios.kechagias@liu.se.ORCID http://orcid.org/0000-0001-7614-739X
Mattias EkstedtDepartment of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden.ORCID http://orcid.org/0000-0002-5590-8601
Christian SimonssonCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0003-3805-1674
Patrik NasrDepartment of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden.ORCID http://orcid.org/0000-0002-2928-4188
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome and is characterized by ectopic accumulation of triglycerides in the cytoplasm of hepatocytes, i.e., steatosis. NAFLD has become the most common chronic liver disease, with an estimated global prevalence of 25%. Although the majority of NAFLD patients will never experience liver-related complications, the progressive potential of NAFLD is indisputable, with 5-10% of subjects progressing to cirrhosis, end-stage liver disease, or hepatocellular carcinoma. NAFLD patients with advanced fibrosis are at the highest risk of developing cardiovascular and cirrhosis-related complications. Liver biopsy has hitherto been considered the reference method for evaluation of hepatic steatosis and fibrosis stage. Given the limitations of biopsy for widescale screening, non-invasive tests (NITs) for assessment of steatosis and fibrosis stage, including serum-based algorithms and ultrasound- and magnetic resonance-based methods, will play an increasing role in the management of NAFLD patients. This comprehensive review presents the advantages and limitations of NITs for identification of steatosis and advanced fibrosis in NAFLD. The clinical implications of using NITs to identify and manage NAFLD patients are also discussed.

Indexed as

Liver NeoplasmsNon-alcoholic Fatty Liver DiseaseBiopsyFibrosisHumansLiverLiver CirrhosisFibrosisNon-alcoholic fatty liver diseaseNon-invasive testsSteatosis

Identifiers

PMID35661987
PMCPMC9464753
OpenAlexW4281844648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.