Evidence map›Paper›PMID 35661971›Full record

ArticleImmunologic research2022

Effect of different cytokines in combination with IL-15 on the expression of activating receptors in NK cells of patients with Behçet's disease.

Nilgun Sallakci, Ilhan Tahrali, Umut Can Kucuksezer, Esin Aktas Cetin, Ahmet Gul, Gunnur Deniz

Abstract read
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In one paragraph

Article in Immunologic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Deficiency of peripheral CLAArthritis research & therapy · 2024
    Article
  4. The roles of immune cells in Behçet's disease.Advances in rheumatology (London, England) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nilgun Sallakci *Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba St. 34093, Istanbul, Turkey.
Ilhan Tahrali *Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba St. 34093, Istanbul, Turkey.
Umut Can KucuksezerDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba St. 34093, Istanbul, Turkey.
Esin Aktas CetinDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba St. 34093, Istanbul, Turkey.
Ahmet GulIstanbul Faculty of Medicine, Department of Rheumatology, Istanbul University, Istanbul, Turkey.
Gunnur DenizDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba St. 34093, Istanbul, Turkey. gdeniz@istanbul.edu.tr.ORCID 0000-0002-0721-6213
Istanbul University · TRAkdeniz University · TRHUN-REN Institute of Experimental Medicine · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behçet's disease (BD) is a systemic, autoinflammatory, chronic disorder which affects various parts of the body in genetically susceptible individuals. BD has a multi-factorial etiopathogenesis which encompasses both innate and adaptive arms of immunity. NK cells, which kill virus-infected or malign cells and provide interaction between adaptive and innate immune system, are also known to involve in the pathogenesis of autoimmune/autoinflammatory diseases including BD. NK cells function in immune responses via the signals obtained from surface-expressed activating and inhibitory receptors. In this study, we aimed to explore NK cell activation status by measuring the levels of activation marker CD69 and activating receptors NKG2D, NKp30, and NKp46 as well as proliferative and cytotoxic capacities in response to stimulation with interleukin (IL)-15-combined cytokines in BD patients. CD4

Indexed as

Behcet SyndromeCytokinesHumansInterleukin-15Killer Cells, NaturalNK Cell Lectin-Like Receptor Subfamily KCytokinesInterleukin-15NK Cell Lectin-Like Receptor Subfamily KBehçet’s diseaseInterleukin-15NK cellsNKG2DNKp30NKp46

Identifiers

PMID35661971
OpenAlexW4281788297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.