ArticleSchizophrenia bulletin2022
Neural Correlates of Variation in Personal Space and Social Functioning in Schizophrenia and Healthy Individuals.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- L'espace vécu and Its Perturbations in Schizophrenia: Systematic Review and Meta-analysis of Altered Body-Centric Metrics-Personal and Peripersonal Space.Schizophrenia bulletin · 2025Pooled it
- Enhancing social functioning using multi-user, immersive virtual reality.Scientific reports · 2025Trial
- Article
- Spatial disruptions and the embodied Self in schizophrenia: toward a developmental framework.Schizophrenia (Heidelberg, Germany) · 2026Review
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- From neuronal to mental topography - Neurophenomenology of auditory hallucinations.Translational psychiatry · 2025Review
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Aberrant personal space is associated with paranoia, altered stress regulation, and unfavourable outcomes at 6 months' follow-up in schizophrenia.Molecular psychiatry · 2025Article
- Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex.Molecular psychiatry · 2025Article
- I fear you're getting too close: neural correlates of personal space violation in paranoia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Altered representation of peripersonal and interpersonal space in psychopathology.Clinical psychology review · 2024Review
- Arousal responses to personal space intrusions in psychotic illness: A virtual reality study.Schizophrenia research · 2024Article
- Article
- Social Withdrawal, Loneliness, and Health in Schizophrenia: Psychological and Neural Mechanisms.Schizophrenia bulletin · 2023Article
- Article
- Interdigitated Columnar Representation of Personal Space and Visual Space in Human Parietal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Personal space increases during the COVID-19 pandemic in response to real and virtual humans.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChanges in the regulation of interpersonal distance, or "personal space" (PS), have been repeatedly observed in schizophrenia and, in some studies, linked to negative symptoms. However, the neurobiological basis of these impairments is poorly understood.
methodsPersonal space measurements, functional connectivity of a brain network sensitive to intrusions into PS, and symptoms of social withdrawal and anhedonia were assessed, and associations among these outcomes measured, in 33 individuals with a psychotic disorder (primarily schizophrenia [SCZ]) and 36 control subjects (CON).
resultsPersonal space size was significantly higher (P = .002) and PS permeability (reflecting the capacity to tolerate intrusions into PS) was significantly lower (P = .021) in the SCZ relative to the CON group, and both measures were significantly correlated with social anhedonia and withdrawal in the full sample (all P < .007). Moreover, functional connectivity between the PS and default mode (DM) networks was significantly correlated with the permeability, but not the size, of PS in the full sample and in the SCZ and CON groups separately, and with social withdrawal in the SCZ group. Lastly, the association between PS-DM network connectivity and social withdrawal in the SCZ group was fully mediated by PS permeability. DISCUSSION: Neural and behavioral aspects of PS regulation are linked to social motivation in both healthy individuals and those with psychotic disorders, suggesting that measurements of PS could serve as transdiagnostic markers of social functioning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.