ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men.GeroScience · 2026Article
- The Muscle Function Deficit Concept and Inflammaging.Biomedicines · 2026Article
- Myosteatosis: an emerging biomarker of aging.Frontiers in aging · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Paraspinous muscle sarcopenic indices for predicting mortality in patients undergoing hemodialysis.Renal failure · 2025Article
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
- Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide.Reviews in endocrine & metabolic disorders · 2025Review
- Biomarkers and Clinical Evaluation in the Detection of Frailty.International journal of molecular sciences · 2025Review
- Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults.Archives of gerontology and geriatrics · 2025Article
- Impact of Muscle Quality on Muscle Strength and Physical Performance Beyond Muscle Mass or Diabetes Status.Journal of cachexia, sarcopenia and muscle · 2025Article
- Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies.Diabetes & metabolism journal · 2023Review
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Authors and funding
9 authors.
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Abstract
backgroundAfrican Caribbeans have higher levels of myosteatosis than other populations; however, little is known about the impact of myosteatosis on physical function in African Caribbeans. Herein, we examined the association between regional myosteatosis of the calf, thigh, and abdomen versus physical function in 850 African-Ancestry men aged 64.2 ± 8.9 (range 50-95) living on the Caribbean Island of Tobago.
methodsMyosteatosis was measured using computed tomography and included intermuscular adipose tissue (IMAT) and muscle density levels of the thigh, calf, psoas, and paraspinous muscles. Outcomes included grip strength, time to complete 5 chair-rises, and 4-meter gait speed. Associations were quantified using separate linear models for each myosteatosis depot and were adjusted for age, height, demographics, physical activity, and chronic diseases. Beta coefficients were presented per standard deviation of each myosteatosis depot.
resultsHigher thigh IMAT was the only IMAT depot significantly associated with weaker grip strength (β = -1.3 ± 0.43 kg, p = .003). However, lower muscle density of all 4 muscle groups was associated with weaker grip strength (all p < .05). Calf and thigh myosteatosis (IMAT and muscle density) were significantly associated with both worse chair rise time and gait speed (all p < .05), whereas psoas IMAT and paraspinous muscle density were associated with gait speed.
conclusionMyosteatosis of the calf and thigh-but not the abdomen-were strongly associated with grip strength and performance measures of physical function in African Caribbean men. However, posterior abdominal myosteatosis may have some utility when abdominal images are all that are available.
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