ArticleBone marrow transplantation2022
C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy.
Abstract readLetter
In one paragraph
Article in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Outcomes of Terminal Complement Blockade in Adults with High-Risk Transplant-Associated Thrombotic Microangiopathy: A Comparative Analysis.Transplantation and cellular therapy · 2026Article
- Deposition of complement components C5b-9 and MASP2 in tissues is not a feature of GVHD and may assist in discriminating GVHD from thrombotic microangiopathy following allogenic transplantation.Bone marrow transplantation · 2023Article
- Microvascular C5b-9 deposition in non-lesional skin in patients with SLE and its correlation with active lupus nephritis: a prospective observational study.Lupus science & medicine · 2023Observational
- MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence.Clinical and experimental immunology · 2023Article
- Narsoplimab for severe transplant-associated thrombotic microangiopathy.Thrombosis journal · 2023Article
- Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches.The Journal of clinical investigation · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Sonia ElhadadDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Amy ChadburnDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-9499-8638
Cynthia MagroDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Koen Van BesienDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-8164-6211
Elisha D O RobersonDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5921-2399
John P AtkinsonDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-2514-3441
Hunter TerryDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
June GreenbergDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Whitney ReidDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
John ChapinDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Dennis CopertinoDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-3217-4713
Sahar GeramfardDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Lizamarie Bachier RodriguezDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Nina OrfaliDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Usama GerghisDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Tsiporah ShoreDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0001-6033-0747
Sebastian MayerDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA.
Jasimuddin AhamedOklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Jeffrey LaurenceDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA. jlaurenc@med.cornell.edu.ORCID http://orcid.org/0000-0002-8274-3144
Cornell University · USWashington University in St. Louis · USMontefiore Medical Center · USOklahoma Medical Research Foundation · US
Funding
Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8MThe Role of TGF-beta Activation and Signaling in Aortic Stenosis ProgressionR01HL148123 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI Jasimuddin Ahamed · 2020 to 2026
$2.9MINTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7MDefining the Complosome in Human Cells, Tissues and Disease StatesR35GM136352 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2020 to 2024
$2.0MThe Mechanism of Shear-Induced Release and Activation of TGF-beta1R01HL123605 · NHLBI · ROCKEFELLER UNIVERSITY · PI AHAMED, JASIMUDDIN · 2015 to 2018
$1.7MNHLBI NIH HHS R01 HL123605NHLBI NIH HHS R01 HL148123NHLBI NIH HHS U54 HL112303NIGMS NIH HHS R01 GM099111
Abstract
PubMed holds no abstract for this paper.
Indexed as
Hematopoietic Stem Cell TransplantationThrombotic MicroangiopathiesBone MarrowComplement Membrane Attack ComplexHumansMannose-Binding Protein-Associated Serine ProteasesMicrovesselsComplement Membrane Attack ComplexMannose-Binding Protein-Associated Serine ProteasesMASP2 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.