Evidence map›Paper›PMID 35661789›Full record

ArticleScientific reports2022

Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption.

F K El Banna, J M Otto, S M Mulloy, W Tsai, S M McElroy, A L Wong, G Cutts, S I Vrieze, A M Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The association between theArhiv za higijenu rada i toksikologiju · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

F K El BannaDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
J M OttoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
S M MulloyDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
W TsaiDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
S M McElroyDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
A L WongDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
G CuttsDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
S I VriezeDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
A M LeeDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA. amlee@umn.edu.
University of Minnesota · US

Funding

Deep Sequencing, Phenotyping, and Imputation in Large-Scale Biobanks: A Novel and Cost-Effective Framework to Identify Rare Mutations Associated with AddictionR01DA044283 · NIDA · UNIVERSITY OF MINNESOTA · PI ALBERT, FRANK WOLFGANG, VRIEZE, SCOTT IAN · 2019 to 2024
$3.2M
Dissecting nicotinic receptor contributions to alcohol aversionR01AA026598 · NIAAA · UNIVERSITY OF MINNESOTA · PI LEE, ANNA M. · 2018 to 2022
$1.7M
NIAAA NIH HHS R01 AA026598NIDA NIH HHS R01 DA044283
6 · The paper itself

Abstract

Alcohol and tobacco are the most commonly used addictive substances, with high comorbidity rates between alcohol use disorder and tobacco use disorder. Risk for alcohol and nicotine addiction is highly heritable, and they share common genetic factors. A GWAS in over 1 million individuals has revealed 566 genetic variants in 406 loci associated with multiple stages of alcohol and tobacco use. Three novel genes-SLC39A8, GRK4 and HGFAC-within loci associated with altered alcoholic drinks per week (ADW) or cigarettes per day (CPD) were selected to further study their role in alcohol and tobacco use disorder. The role of these genes was assessed using the two-bottle choice addiction paradigm in transgenic mice for each of the genes. We found significant decreases in chronic alcohol consumption and preference in female Hgfac knockout (KO) mice, and decreased nicotine preference in male Hgfac KO compared with wild-type (WT) mice. Additionally, male Slc39a8 hypomorph mice showed greater overall nicotine preference compared with WT mice, while no differences were detected for Grk4 KO mice in alcohol or nicotine consumption and preference in either sex. Thus, this study implicates Hgfac and Slc39a8 in alcohol and tobacco use in a sex-specific manner.

Indexed as

Cation Transport ProteinsTobacco Use DisorderAlcohol DrinkingAnimalsEthanolFemaleGenome-Wide Association StudyMaleMiceMice, KnockoutModels, AnimalNicotineCation Transport ProteinsEthanolNicotineSlc39a8 protein, mouse

Identifiers

PMID35661789
PMCPMC9167284
OpenAlexW4281878980

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.