ArticleEuropean journal of radiology2022
Incomplete circle of Willis variants and stroke outcome.
Article in European journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Circle of Willis Configuration and Thrombus Localization Impact on Ischemic Stroke Patient Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Carotid plaque vulnerability and circle of Willis anatomy predict ipsilateral brain infarcts and long-term mortality in carotid endarterectomy patients.GeroScience · 2026Article
- A review of animal models of vascular dementia.Molecular biology reports · 2026Review
- A Subject-Specific Cerebrovascular CFD Modeling Approach Based on a Multimodal Data-Driven Boundary Calibration Framework: A Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2026Article
- How I do it: Zone 0 arch treatment with laser in situ fenestrated endograft repair.Journal of vascular surgery cases and innovative techniques · 2026Article
- Incompleteness of the circle of Willis affects sleep quality, cognitive function and inflammation in patients with primary hypertension.The journal of physiological sciences : JPS · 2025Article
- Article
- Differential impact of cerebral small vessel disease on thalamic regulation of anxiety: insights from 7T MRI.Molecular psychiatry · 2025Article
- Bilateral anterior cerebral artery-anterior communicating artery junction arterial ring (duplicate origin of the A2) associated with unilateral A1 aplasia diagnosed by magnetic resonance angiography.Surgical and radiologic anatomy : SRA · 2025Article
- The impact of circle of Willis integrity and variations on clinical and radiological outcomes after posterior communicating arteries covered by flow diverter devices.Neurosurgical review · 2025Article
- Anomalous vertebral arteries and recurrent ischemic stroke: Insights from a unique case (first documented case-report from Syria).Medicine · 2025Article
- Circle of Willis Variants and Their Association with Outcome after Successful Revascularization of Anterior Large Vessel Occlusion.AJNR. American journal of neuroradiology · 2025Article
- Right aortic arch with aberrant left subclavian artery and anomalous Circle of Willis supply.Radiology case reports · 2025Article
- Patterns of Circle of Willis Variants among Patients Undergoing 3 Tesla Magnetic Resonance Angiography at a Tertiary Care Hospital: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study.BMC medical imaging · 2025Article
- Detection, cerebrovascular complications and risk factors associated with vertebrobasilar dolichoectasia: a scoping review.Frontiers in neurology · 2025Review
- High-Resolution MRA Cerebrovascular Findings in a Tri-Ethnic Population.AJNR. American journal of neuroradiology · 2024Article
- Collateral is brain: Low perfusion triggers spreading depolarization and futile reperfusion after acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Communicating Arteries and Leptomeningeal Collaterals: A Synergistic but Independent Effect on Patient Outcomes after Stroke.Neurology international · 2024Article
- Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is considerable variation in circle of Willis morphology among the general population, and these variations have been correlated with risk of aneurysms, cerebral ischemia, and other clinical events. PURPOSE: To investigate the relationship between circle of Willis variants and stroke outcome. MATERIALS AND
methodsWe performed a retrospective study involving 297 patients from our institution's acute stroke academic registry. All received MRA examinations of the head upon admission for acute strokes. All imaging was reviewed to assess for circle of Willis variants (particularly A1 and P1 aplasia or hypoplasia) along with vertebral artery aplasia or hypoplasia. Stroke outcome was defined as good (walking independently at the time of discharge) or poor (inability to walk at discharge, assistance needed to walk at discharge, or death). Severity of stroke was assessed using the National Institute of Health Stroke Scale.
resultsAn incomplete circle of Willis was seen in 34% of subjects. There was no significant association between age, gender, hypertension, or presence of arterial stenosis and circle of Willis completeness. Using logistic regression, we found that the presence of an incomplete circle of Willis decreased the odds of a stroke patient having a good outcome by 47% (p = 0.046, OR 0.53, 95% CI 0.281-0.988), after adjusting for age and severity of stroke at admission.
conclusionThis study suggests that an incomplete circle of Willis may be associated with a poorer prognosis for stroke patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.