ReviewBiological trace element research2023
Necessity to Pay Attention to the Effects of Low Fluoride on Human Health: an Overview of Skeletal and Non-skeletal Damages in Epidemiologic Investigations and Laboratory Studies.
Review in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Fluoride Exposure and Skeletal Fluorosis: a Systematic Review and Dose-response Meta-analysis.Current environmental health reports · 2023Pooled it
- Fluoride exposure induces oxidative damage in primary astrocytes of SD rats and changes in the expression of α-synuclein and its effect on Nrf2-NQO1/HO-1 signaling pathway.Journal of bioenergetics and biomembranes · 2026Article
- Fluoride Damages the Ovary by Inhibiting LKB1-AMPK Signaling to Promote Mitochondrial Injury-Induced Inflammation and Oxidative Stress.Biological trace element research · 2026Article
- Eco-Friendly Low-Cost Design of Superhydrophobic Cu Mesh for Efficient Oil-Water Separation.Molecules (Basel, Switzerland) · 2026Article
- FI-RADS: an imaging-based scoring system for skeletal fluorosis-adjunctive clinical and biochemical analysis.Quantitative imaging in medicine and surgery · 2026Article
- The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.Biological trace element research · 2025Article
- Low Fluoride Regulates Macrophage Polarization Through Mitochondrial Autophagy Mediated by PINK1/Parkin Axis.Biomolecules · 2025Article
- Article
- Sodium fluoride accelerates apoptosis, oxidative stress and matrix degradation of condylar chondrocytes by upregulating MMP-13 and RANKL.American journal of translational research · 2025Article
- A cross-sectional study of dietary and urinary soy isoflavones about coal-burning fluorosis in Guizhou, China.Frontiers in nutrition · 2025Article
- Fluoride Exposure from Drinking Water Increases the Risk of Stroke: An Ecological Study in Changwu Town, China.Toxics · 2024Article
- The Association between Fluoride and Bone Mineral Density in US Children and Adolescents: A Pilot Study.Nutrients · 2024Article
- Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China.Frontiers in public health · 2024Article
- Progress in research on the role of fluoride in immune damage.Frontiers in immunology · 2024Review
- Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.Biological trace element research · 2023Article
- Fluoride - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the implementation of water improvement and fluoride reduction plans supported by central and local governments in recent years, areas with high fluoride exposure are being gradually decreased. Therefore, it is of practical importance to study the effect of low fluoride on human health. Epidemiologic investigations and in vivo and in vitro studies based on low fluoride have also confirmed that fluoride not only causes skeletal damage, such as dental fluorosis, but also causes non-skeletal damage involving the cardiovascular system, nervous system, hepatic and renal function, reproductive system, thyroid function, blood glucose homeostasis, and the immune system. This article summarizes the effects of low fluoride on human and animal skeletal and non-skeletal systems. A preliminary exploration of corresponding mechanisms that will help to fully understand the harm of low fluoride on human health was undertaken to provide the basis for establishing new water fluoride standards and help to implement individual guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.