ArticleNature communications2022
Adaptive liquid interfaces induce neuronal differentiation of mesenchymal stem cells through lipid raft assembly.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- From Inception to Innovation: 20 Years of Nanoarchitectonics.Chemistry, an Asian journal · 2025Review
- Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix's Complexity.ACS nano · 2025Review
- Potential-Switchable Viscoelasticity of Protein Nanolayers at a Liquid/Liquid Interface.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Assembly and Functionality of 2D Protein Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Lateral nanoarchitectonics from nano to life: ongoing challenges in interfacial chemical science.Chemical science · 2024Review
- Patterning Bacterial Cells on Quasi-Liquid Surfaces for Biofilm Morphological Control.Advanced functional materials · 2024Article
- Formulate Adaptive Biphasic Scaffold via Sequential Protein-Instructed Peptide Co-Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Liquid-Liquid and Liquid-Solid Interfacial Nanoarchitectonics.Molecules (Basel, Switzerland) · 2024Review
- A novel strategy to facilitate uniform epithelial cell maturation using liquid-liquid interfaces.Scientific reports · 2024Article
- Lipid Rafts: The Maestros of Normal Brain Development.Biomolecules · 2024Review
- 2D Materials Nanoarchitectonics for 3D Structures/Functions.Materials (Basel, Switzerland) · 2024Review
- Data-driven optimization of theScience and technology of advanced materials · 2024Article
- Crucial Factors Influencing the Involvement of Odontogenic Exosomes in Dental Pulp Regeneration.Stem cell reviews and reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells and their microenvironment interact cooperatively to dictate their fates. Biomaterials are dynamically remodeled by stem cells, and stem cells sense and translate the changes into cell fate decisions. We have previously reported that adaptive biomaterials composed of fibronectin inserted into protein nanosheets at a liquid interface enhance neuronal differentiation of human mesenchymal stem cells (hMSCs). However, we could not decouple clearly the effect of ligand density from that of fibrillary structure on cellular function and fate. Here we present an adaptive biomaterial based on two-dimensional networks of protein nanofibrils at a liquid-liquid interface. Compared with flat protein nanosheets, this biomaterial enhances neuronal differentiation of hMSCs through a signaling mechanism involving focal adhesion kinase. Lipid raft microdomains in plasma membrane are found to play a central role in which hMSCs rapidly adapt to the dynamic microenvironment at the fluid interface. Our finding has substantial implications for regenerative medicine and tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.