Evidence map›Paper›PMID 35660992›Full record

ArticleTalanta2022

A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection.

Mahnaz D Gholami, Kristyan Guppy-Coles, Serena Nihal, Daman Langguth, Prashant Sonar, Godwin A Ayoko, Chamindie Punyadeera, Emad L Izake

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Talanta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mahnaz D GholamiSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Kristyan Guppy-ColesSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Serena NihalSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Daman LangguthDepartment of Clinical Immunology and Allergy, Wesley Hospital, Brisbane, QLD, 4066, Australia; Department of Immunology, Sullivan Nicolaides Pathology, QLD, 4006, Australia.
Prashant SonarSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia; Centre for Materials Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia; Centre for Biomedical Technology, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Godwin A AyokoSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia; Centre for Materials Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia.
Chamindie PunyadeeraGriffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, QLD, 4111, Australia; Menzies Health Institute Queensland (MIHQ), Griffith University, Brisbane, QLD, 4111, Australia.
Emad L IzakeSchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia; Centre for Materials Science, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia; Centre for Biomedical Technology, Queensland University of Technology (QUT), Brisbane, QLD, 4000, Australia. Electronic address: e.kiriakous@qut.edu.au.
Queensland University of Technology · AUGriffith University · AUWesley Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to human health. Current methods such as reverse transcription polymerase chain reaction (qRT-PCR) are complex, expensive, and time-consuming. Rapid, and simple screening methods for the detection of SARS-CoV-2 are critically required to fight the current pandemic. In this work we present a proof of concept for, a simple optical sensing method for the screening of SARS-CoV-2 through its spike protein subunit S1. The method utilizes a target-specific extractor chip to bind the protein from the biological specimens. The disulfide bonds of the protein are then reduced into a biothiol with sulfhydryl (SH) groups that react with a blue-colored benzothiazole azo dye-Hg complex (BAN-Hg) and causes the spontaneous change of its blue color to pink which is observable by the naked eye. A linear relationship between the intensity of the pink color and the logarithm of reduced S1 protein concentration was found within the working range 130 ng.mL

Indexed as

COVID-19MercuryCysteineHumansMembrane ProteinsSARS-CoV-2CysteineMembrane ProteinsMercuryBiothiolColorimetric assayPaper based sensorSARS-CoV-2

Identifiers

PMID35660992
PMCPMC9153203
OpenAlexW4281686287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.