Evidence map›Paper›PMID 35660731›Full record

ArticleMedicina oral, patologia oral y cirugia bucal2022

IL-10 and TGF-β1 gene polymorphisms in Greek patients with recurrent aphthous stomatitis.

V Kounoupis, D Andreadis, M Georgaki, E Albanidou-Farmaki, M Daniilidis, A Markopoulos, N Karyotis, N-G Nikitakis, A Poulopoulos

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina oral, patologia oral y cirugia bucal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07565181 (Evaluation of Zinc Oxide Ointment in Treatment of Recurrent Aphthous Stomatitis), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07565181 phase4completednot on this mapstarted 2025, after this paper: background citation

Evaluation of Zinc Oxide Ointment in Treatment of Recurrent Aphthous Stomatitis

TypeinterventionalSponsorFaculty of Dental Medicine for GirlsRan2025 to 2026Enrolled100ConditionsRecurrent Aphthous StomatitisArmszinc oxide, Placabo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

V KounoupisDepartment of Oral Medicine and Pathology and Hospital Dentistry School of Dentistry, National and Kapodistrian University of Athens 2 Thivon St., Goudi 11527, Athens, Greece mar1georgaki@gmail.com.
D Andreadis
M Georgaki
E Albanidou-Farmaki
M Daniilidis
A Markopoulos
N Karyotis
N-G Nikitakis
A Poulopoulos
Aristotle University of Thessaloniki · GRNational and Kapodistrian University of Athens · GRAHEPA University Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent aphthous stomatitis (RAS) is one of the most frequent inflammatory disorders of the oral mucosa. Cytokines, which play an important role in RAS pathogenesis, participate directly or indirectly in normal, immunological and inflammatory processes and are secreted from cells belonging to innate and adaptive immunity as a consequence of microbial and antigenic stimuli. Gene polymorphisms in specific cytokines may predispose to RAS development. The aim of this study was the investigation and association of IL-10 and TGF-β1 gene polymorphisms with RAS. MATERIAL AND

methodsStudy's cohort consisted of 60 Greek patients diagnosed with RAS, including 40 patients with minor, 10 patients with major and 10 with herpetiform aphthous ulcers. Forty age- and sex-matched control subjects were included in this study. DNA was extracted from whole blood samples of all patients and sequence-specific primers (SSP)-based polymerase chain reaction (PCR) was used for genotyping. Gene polymorphisms for cytokines IL-10 at loci -592 and -819 and for TGF-β1 at codon 10 were detected.

resultsSignificant differences between patients with minor RAS and healthy controls were recorded for IL-10 genotypes distribution at position -592 (p=0.042) and -819 (p=0.045) with predominance of C/A and C/T genotypes in RAS patients, respectively. Also, in patients with minor and herpetiform aphthous ulcerations, heterozygous TGF-β1 genotype C/T at codon 10 was associated with increased risk of RAS (p=0.044 and p=0.020, respectively).

conclusionsThese data provide evidence that genetic predisposition for RAS and possibly its specific clinical variants is related with the presence of gene polymorphisms for specific cytokines, including IL-10 and TGF-β1, which, in turn, may vary according to geographic origin and genetic background.

Indexed as

Interleukin-10Stomatitis, AphthousTransforming Growth Factor beta1Case-Control StudiesCodonGenetic Predisposition to DiseaseGenotypeGreeceHumansPolymorphism, Single NucleotideCodonIL10 protein, humanInterleukin-10TGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID35660731
PMCPMC9445602
OpenAlexW4282943911

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.