Evidence map›Paper›PMID 35660485›Full record

ArticleContemporary clinical trials2022

Rationale and design of a randomized controlled clinical trial; Titration of Oxygen Levels (TOOL) during mechanical ventilation.

Sonal R Pannu, Tyler Haddad, Matthew Exline, John W Christman, Jeffrey C Horowitz, Jonathan Peters, Guy Brock, Philip Diaz, Elliott D Crouser

Open access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sonal R PannuThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States. Electronic address: sonal.pannu@osumc.edu.
Tyler HaddadThe Ohio State University, Department of Internal Medicine, Columbus, OH, United States.
Matthew ExlineThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States.
John W ChristmanThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States.
Jeffrey C HorowitzThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States.
Jonathan PetersThe Ohio State University, Department of Respiratory Therapy, Columbus, OH, United States.
Guy BrockThe Ohio State University, Center for Biostatistics and Bioinformatics, Columbus, OH, United States.
Philip DiazThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States.
Elliott D CrouserThe Ohio State University, Division of Pulmonary, Critical Care & Sleep Medicine, Columbus, OH, United States.
The Ohio State University · US

Funding

REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN ARDSR01HL137224 · NHLBI · OHIO STATE UNIVERSITY · PI CHRISTMAN, JOHN W, KARPURAPU, MANJULA · 2018 to 2025
$4.5M
Institutional Career Development CoreKL2TR002734 · NCATS · OHIO STATE UNIVERSITY · PI CARNES, CYNTHIA A · 2018 to 2022
$2.7M
X-Linked Inhibitor of Apoptosis in Fibroblast Phenotypes and Lung FibrosisR01HL141195 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOROWITZ, JEFFREY C · 2018 to 2021
$2.3M
NCATS NIH HHS KL2 TR002734NHLBI NIH HHS R01 HL137224NHLBI NIH HHS R01 HL141195
6 · The paper itself

Abstract

backgroundBoth hyperoxemia and hypoxemia are deleterious in critically ill patients. Targeted oxygenation is recommended to prevent both of these extremes, however this has not translated to the bedside. Hyperoxemia likely persists more than hypoxemia due to absence of immediate discernible adverse effects, cognitive biases and delay in prioritization of titration.

methodsWe present the methodology for the Titration Of Oxygen Levels (TOOL) trial, an open label, randomized controlled trial of an algorithm-based FiO

conclusionThis study is designed to evaluate the efficacy of a high fidelity, bioinformatics-based, electronic medical record derived electronic alert system to improve targeted oxygenation in mechanically ventilated patients by reducing excessive FiO

Indexed as

OxygenRespiration, ArtificialCritical IllnessHumansHypoxiaLungRandomized Controlled Trials as TopicOxygenElectronic alertsElectronic medical recordsHyperoxiaMechanical ventilationOxygenProtocolRandomized clinical trials

Identifiers

PMID35660485
PMCPMC11114599
OpenAlexW4281680788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.