Evidence map›Paper›PMID 35660266›Full record

ReviewCurrent opinion in structural biology2022

Diversity of function and mechanism in a family of organic anion transporters.

Fei Li, Jacob Eriksen, Janet Finer-Moore, Robert M Stroud, Robert H Edwards

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fei LiDepartment of Biochemistry & Biophysics, UCSF School of Medicine, CA, USA; Departments of Neurology and Physiology, UCSF School of Medicine, CA, USA. Electronic address: https://twitter.com/Fei_UCSF.
Jacob EriksenDepartments of Neurology and Physiology, UCSF School of Medicine, CA, USA. Electronic address: https://twitter.com/jcbrksn.
Janet Finer-MooreDepartment of Biochemistry & Biophysics, UCSF School of Medicine, CA, USA.
Robert M StroudDepartment of Biochemistry & Biophysics, UCSF School of Medicine, CA, USA. Electronic address: https://twitter.com/lab_stroud.
Robert H EdwardsDepartments of Neurology and Physiology, UCSF School of Medicine, CA, USA. Electronic address: robert.edwards@ucsf.edu.
Twitter (United States) · USUniversity of California, San Francisco · US

Funding

STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Structural Basis of Vesicular Neurotransmitter TransportR01NS089713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H, STROUD, ROBERT M · 2015 to 2023
$5.8M
TRANSPORT OF NEUROTRANSMITTERS INTO SYNAPTIC VESICLESR01MH050712 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H · 1993 to 2011
$3.8M
Structural Basis of Quantal ReleaseK99MH119591 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, FEI · 2019 to 2020
$242k
NIGMS NIH HHS R01 GM024485NIMH NIH HHS K99 MH119591NIMH NIH HHS R01 MH050712NINDS NIH HHS R01 NS089713
6 · The paper itself

Abstract

Originally identified as transporters for inorganic phosphate, solute carrier 17 (SLC17) family proteins subserve diverse physiological roles. The vesicular glutamate transporters (VGLUTs) package the principal excitatory neurotransmitter glutamate into synaptic vesicles (SVs). In contrast, the closely related sialic acid transporter sialin mediates the flux of sialic acid in the opposite direction, from lysosomes to the cytoplasm. The two proteins couple in different ways to the H

Indexed as

Organic Anion TransportersSynaptic VesiclesAnimalsEscherichia coliGlutamic AcidMembrane Transport ProteinsRatsSubstrate SpecificityGlutamic AcidMembrane Transport ProteinsOrganic Anion Transporters

Identifiers

PMID35660266
PMCPMC9884543
OpenAlexW4282002730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.