ArticleCancer cell2022
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Cancer cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07354971 (The Immuno-FIT Observational Study), which is not on this map. Cited by 168 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 2 pooled it
18.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Immuno-FIT Observational Study: A Phase II Window Observational Study Investigating the Effects of Immunotherapy on Cardiopulmonary Fitness, Quality of Life, and Treatment Outcomes in Patients With Advanced Cancer
Who cites it
168 citing papers in PubMed, 2 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Comparison of different exercise modalities on chronic inflammation and immune function in cancer survivors: a systematic review with network, dose-response, and Bayesian meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Engineering cytokines for cancer immunotherapy: a systematic review.Frontiers in immunology · 2023Pooled it
- Impact of exercise training on tumour-infiltrating T cells in human prostate cancer: A secondary analysis of a randomized controlled trial (PRO-TEST).Experimental physiology · 2026Trial
- Lipid metabolism associated with efficacy of metronomic capecitabine and camrelizumab in gastrointestinal cancer: an exploratory clinical trial.BMC medicine · 2025Trial
- Moving for optimal immunity: the effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells.Frontiers in immunology · 2025Trial
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Precision Exercise for Breast Cancer-Related Outcomes: Towards Personalised Training Based on Tumour, Treatment and Patient Characteristics.Sports medicine (Auckland, N.Z.) · 2026Review
- Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026Review
- Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers.iScience · 2026Article
- Collagen-Binding IL-15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self-Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association of objectively assessed physical activity with immune cell infiltration of the tumor microenvironment in non-metastatic colon cancer.International journal of colorectal disease · 2026Observational
- Exercise as a Disease-Modifying Therapy in Colon Cancer: Practice-Changing Evidence from the CHALLENGE Trial.Cancers · 2026Review
- Physical Exercise in Immunotherapy.Sports medicine - open · 2026Review
- Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer.Cancer research · 2026Article
- Exercise Modulates Microbial Metabolites and Induces Stromal Remodeling in Pancreatic Cancer.Cancer research · 2026Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Pancreatic Cancer-Advances in the Last 50 Years.World journal of surgery · 2026Review
- When does exercise hinder rather than halt tumor progression? The decisive role of immunotherapy responsiveness.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Neuro-immune crosstalk in the tumor microenvironment: mechanisms and therapeutic implications for cancer immunotherapy.Journal of neuroinflammation · 2026Review
108 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 1 country.
Emma KurzDepartment of Cell Biology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA.
Carolina Alcantara HirschDepartment of Cell Biology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA.
Tanner DaltonDepartment of Pathology, Columbia University Irving Medical Center, 630 W 168th St., New York, NY 10032, USA.
Sorin Alberto ShadaloeyDepartment of Cell Biology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratory, NYU Grossman School of Medicine, 227 East 30(th) St., New York, NY 10016, USA.
George MillerDepartment of Surgery, Trinity Health New England, 56 Franklin St., Waterbury, CT 06706, USA.
Sumedha PareekDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Hajar RajaeiDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Chirayu MohindrooDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Seyda BaydoganDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
An Ngo-HuangDepartment of Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Nathan ParkerDepartment of Health Outcomes and Behavior, Moffit Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Matthew H G KatzDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Maria PetzelDepartment of Clinical Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Emily VucicDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA.
Florencia McAllisterDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA; Gastrointestinal Medical Oncology and Immunology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston TX, 77030, USA.
Keri SchadlerDepartment of Pediatrics Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Rafael WinogradPermultter Cancer Center, NYU Langone Health, 160 East 34(th) St., New York, NY 10016, USA.
Dafna Bar-SagiDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, 550 1(st) Avenue, New York, NY 10016, USA. Electronic address: dafna.bar-sagi@nyulangone.org.
The University of Texas MD Anderson Cancer Center · USNew York University · USColumbia University Irving Medical Center · USMoffitt Cancer Center · USNYU Langone Health · USTrinity Health · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MProject-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1MInstitutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL, HOCHMAN, JUDITH S · 2012 to 2014
$16.8MMedical Scientist Research Service AwardT32GM136573 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SULMAN, ERIK · 2020 to 2024
$6.8MOncogenic Ras-induced macropinocytosis: A new paradigm for metabolic adaptationR35CA210263 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA · 2016 to 2022
$6.6MResearch Training for Physician-Scientists in Gastrointestinal OncologyT32CA193111 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WOLFGANG, CHRISTOPHER L. · 2015 to 2024
$2.7MDissecting the Source and Mechanisms of IL-17-Mediated Modulation of Pancreatic TumorigenesisR37CA237384 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCALLISTER, FLORENCIA · 2020 to 2025
$2.6MDectin-1 signaling drives pancreatic oncogenesis by inducing macrophage-mediated adaptive immune suppressionR01CA215471 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WONG, KWOK KIN · 2018 to 2022
$2.3MPancFit: Do angiogenic biomarkers correlate with improved progression free survival in pancreatic cancer?R21CA218732 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KATZ, MATTHEW H. G., NGO-HUANG, AN THUY · 2018 to 2019
$377kMultispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359kICOSL Signaling in Macrophages Promotes Anti-Tumor ImmunityF30CA243205 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KURZ, EMMA · 2019 to 2021
$132kNCATS NIH HHS UL1 TR000038NCATS NIH HHS UL1 TR001445NCI NIH HHS F30 CA243205NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA215471NCI NIH HHS R21 CA218732NCI NIH HHS R35 CA210263NCI NIH HHS R37 CA237384NCI NIH HHS T32 CA193111NIGMS NIH HHS T32 GM136573NIH HHS S10 OD021747
Abstract
Aerobic exercise is associated with decreased cancer incidence and cancer-associated mortality. However, little is known about the effects of exercise on pancreatic ductal adenocarcinoma (PDA), a disease for which current therapeutic options are limited. Herein, we show that aerobic exercise reduces PDA tumor growth, by modulating systemic and intra-tumoral immunity. Mechanistically, exercise promotes immune mobilization and accumulation of tumor-infiltrating IL15Rα
Indexed as
Antineoplastic AgentsCarcinoma, Pancreatic DuctalPancreatic NeoplasmsCD8-Positive T-LymphocytesCell Line, TumorHumansImmunotherapyInterleukin-15Receptors, Interleukin-15Tumor MicroenvironmentAntineoplastic AgentsInterleukin-15Receptors, Interleukin-15checkpoint blockadeexerciseIL-15immunologyimmunotherapypancreatic cancerPD-1super-agonistT cell
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Registered trials
NCT07354971ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.