ArticleImmunity & ageing : I & A2022
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study.
Article in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Risk factors for frailty in older adults with cancer: a systematic review.BMC geriatrics · 2026Pooled it
- Immunological Insights into the Causal Link Between Arthritis, Osteoarthritis, and Frailty: An Integrated Analytical Study.International journal of medical sciences · 2025Pooled it
- Genetic predisposition to white blood cells in relation to the risk of frailty.Aging clinical and experimental research · 2023Pooled it
- Association of latent class trajectories of frailty with incident symptomatic knee osteoarthritis in Chinese postmenopausal women: a nationwide cohort study from China.Scientific reports · 2026Article
- Prevalence of preoperative multidimensional frailty and associated factors in middle-aged and older patients with newly diagnosed breast cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Interaction between perceived ageism and poor sleep quality on frailty among community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2026Article
- Autophagy-Mitophagy Pathway-Linked Genetic Variants Associate with Systemic Inflammation and Interact with Dietary Factors in Asian and European Cohorts.International journal of molecular sciences · 2026Article
- Extreme temperature events and frailty progression in middle-aged and older adults: the longitudinal evidence from CHARLS.BMC public health · 2026Article
- Identifying sex-specific predictors of frailty in Korean community-dwelling older adults using interpretable machine learning.BMC geriatrics · 2026Article
- Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study.Lipids in health and disease · 2026Article
- Physical Resilience After Hip Fracture: Unpacking the Roles of Resistance and Recovery.Journal of the American Geriatrics Society · 2025Article
- Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study.Journal of translational medicine · 2025Article
- Sex- and system-specific analysis of blood-based biomarkers and frailty in older adults-the Activity and Function of the Elderly study.Age and ageing · 2025Article
- Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.Nature genetics · 2025Article
- Association Between Preoperative Frailty Using Frailty Index-Laboratory Test and Clinical Outcomes in Older Adults Undergoing Brain Tumor Surgery.Nursing & health sciences · 2025Article
- Explainable machine learning framework for biomarker discovery by combining biological age and frailty prediction.Scientific reports · 2025Article
- Association between cardiometabolic multimorbidity, body roundness index, and frailty index in Chinese middle-aged and older adults.The journal of nutrition, health & aging · 2025Article
- Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging.European geriatric medicine · 2024Article
- A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study.Journal of clinical biochemistry and nutrition · 2024Article
- Association of Air Quality Improvement and Frailty Progression: A National Study across China.Toxics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSystemic inflammation has been linked to diseases and frailty. However, little is known about the effect of systemic inflammation on frailty progression with a longitudinal study design.
objectivesThis study aimed to investigate the associations of two inflammation indicators, C-reactive protein (CRP) and white blood cell (WBC), with frailty progression.
methodsThis study utilized data from the China Health and Retirement Longitudinal Study 2011-2018 (wave 1-wave 4). Frailty index (FI) was calculated using 40 items from wave 1 to wave 4 (range: 0 to 1). Two systemic inflammation biomarkers, CRP and WBC, were measured at baseline (wave 1) and logs transformed as continuous variables or grouped using quartiles. Linear mixed-effect models were used to analyze the associations of these two biomarkers with the progression of frailty with adjustment for potential confounding factors.
resultsThe study enrolled 9111 middle-aged and older participants (52.7% females, mean age 58.8 ± 9.3 years). The median follow-up time was 7.0 years. In a fully adjusted model with further adjustment for baseline FI, higher CRP (β for the interaction with time = 0.239, 95% CI: 0.139 to 0.338) and WBC (β for the interaction with time = 0.425, 95% CI: 0.024 to 0.825) significantly accelerated the rate of increase in the FI during the follow-up period. The associations were more pronounced in younger people (< 60 years) than older people (≥60 years).
conclusionsHigher CRP and WBC accelerated the progression of frailty, particularly in younger groups (< 60 years). The findings suggest the importance of systemic inflammation for the early identification of people at high risk of rapid progression of frailty.
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