Evidence map›Paper›PMID 35659464›Full record

ArticleTissue barriers2023

Critical roles of adherens junctions in diseases of the oral mucosa.

Christina Kingsley, Antonis Kourtidis

Open access · greenAbstract read
In one paragraph

Article in Tissue barriers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christina KingsleyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Antonis KourtidisDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-8128-6391
Medical University of South Carolina · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Evan R Delgado · 2020 to 2026
$18.7M
T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Garth R Swanson · 2020 to 2026
$8.8M
Epithelial adherens junctions regulate colon cell behavior through RNAi and lncRNAsR01DK124553 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KOURTIDIS, ANTONIS · 2021 to 2024
$1.3M
PIWI - Transposon regulation by epithelial adherens junctionsR21CA246233 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KOURTIDIS, ANTONIS · 2020 to 2021
$384k
NCI NIH HHS R21 CA246233NIDCR NIH HHS T32 DE017551NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK124553NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P20 GM130457
6 · The paper itself

Abstract

The oral cavity is directly exposed to a variety of environmental stimuli and contains a diverse microbiome that continuously interacts with the oral epithelium. Therefore, establishment and maintenance of the barrier function of the oral mucosa is of paramount importance for its function and for the body's overall health. The adherens junction is a cell-cell adhesion complex that is essential for epithelial barrier function. Although a considerable body of work has associated barrier disruption with oral diseases, the molecular underpinnings of these associations have not been equally investigated. This is critical, since adherens junction components also possess significant signaling roles in the cell, in addition to their architectural ones. Here, we summarize current knowledge involving adherens junction components in oral pathologies, such as cancer and oral pathogen-related diseases, while we also discuss gaps in the knowledge and opportunities for future investigation of the relationship between adherens junctions and oral diseases.

Indexed as

Adherens JunctionsMouth MucosaSignal Transductioncatenincleft palateE-cadherinoral canceroral cavityoral pathogens

Identifiers

PMID35659464
PMCPMC10161952
OpenAlexW4281936141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.