Evidence map›Paper›PMID 35659306›Full record

ReviewCell communication and signaling : CCS2022

Anastasis: cell recovery mechanisms and potential role in cancer.

Rebar N Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar and 3 more

Erratum issuedAbstract readReviewVideo-Audio Media
In one paragraph

Review in Cell communication and signaling : CCS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Anastasis: an unwelcome guest in cancer therapy.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Review
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  5. Review
  6. Article
  7. Ambiguous Role of p53 in Transcription-Dependent Tumor Cell Death.International journal of molecular sciences · 2026
    Review
  8. Review
  9. Anastasis: Reality or Fiction?Bulletin of experimental biology and medicine · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. A cellular danse macabre: the choreography of programmed cell death.Apoptosis : an international journal on programmed cell death · 2025
    Article
  17. Article
  18. Article
  19. Chromothripsis.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Rebar N Mohammed *Medical Laboratory Analysis Department, College of Health Sciences, Cihan University of Sulaimaniya, Kurdistan Region, Sulaimaniya, Iraq.
Mohsen Khosravi *Department of Psychiatry and Clinical Psychology, Zahedan University of Medical Sciences, Zahedan, Iran.
Heshu Sulaiman RahmanDepartment of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq.
Ali AdiliDepartment of Oncology, Tabriz University of Medical Sciences, Tabriz, Iran.
Navid KamaliImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pavel Petrovich SoloshenkovI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. pavelsoloshenkov@yandex.ru.
Lakshmi ThangaveluDepartment of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, India.
Hossein SaeediImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Navid ShomaliImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rozita TamjidifarImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza IsazadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ramin AslaminabadImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Morteza AkbariImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. akbarimo@tbzmed.ac.ir.ORCID http://orcid.org/0000-0001-7333-1300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Balanced cell death and survival are among the most important cell development and homeostasis pathways that can play a critical role in the onset or progress of malignancy steps. Anastasis is a natural cell recovery pathway that rescues cells after removing the apoptosis-inducing agent or brink of death. The cells recuperate and recover to an active and stable state. So far, minimal knowledge is available about the molecular mechanisms of anastasis. Still, several involved pathways have been explained: recovery through mitochondrial outer membrane permeabilization, caspase cascade arrest, repairing DNA damage, apoptotic bodies formation, and phosphatidylserine. Anastasis can facilitate the survival of damaged or tumor cells, promote malignancy, and increase drug resistance and metastasis. Here, we noted recently known mechanisms of the anastasis process and underlying molecular mechanisms. Additionally, we summarize the consequences of anastatic mechanisms in the initiation and progress of malignancy, cancer cell metastasis, and drug resistance. Video Abstract.

Indexed as

Cell Death ReversalNeoplasmsApoptosisCell DeathCell SurvivalDNA DamageHumansAnastasisApoptosisChemotherapyDrug resistance

Identifiers

PMID35659306
PMCPMC9166643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.