Evidence map›Paper›PMID 35659287›Full record

ArticleBMC pulmonary medicine2022

Multiple breath washout lung function reveals ventilation inhomogeneity unresponsive to mechanical assisted cough in patients with neuromuscular disease.

Mathis Steindor, Anna Pichler, Laura Heitschmidt, Eva Pitsikoulis, Alexandra Kavvalou, Eser Orhan, Margerete Olivier, Florian Stehling

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mathis SteindorPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany. mathis.steindor@uk-essen.de.
Anna PichlerPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Laura HeitschmidtPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Eva PitsikoulisPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Alexandra KavvalouPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Eser OrhanPediatric Research Network Essen, Essen, Germany.
Margerete OlivierPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Florian StehlingPediatric Pulmonology and Sleep Medicine, Department of Paediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
University of Duisburg-Essen · DEEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory involvement defines the clinical outcome of neuromuscular diseases (NMD). The lung clearance index (LCI) is a marker of lung ventilation inhomogeneity and indicates small airway disease. It is determined by mulitple breath washout lung function (MBW). The merit of LCI is undisputed for primary lung diseases like cystic fibrosis, but its role in NMD is unclear.

methodsWe investigated the role of MBW in patients with NMD and the effect of two different tracer gases and cough assist devices on the LCI. Patients and controls performed MBW with nitrogen (N

results24 NMD patients (12 Duchenne Muscular Dystrophy, 8 Spinal Muscular Atrophy, 4 other NMDs) and 15 healthy controls were enrolled. In the NMD group, overall LCI N

conclusionLung involvement of patients with neuromuscular diseases goes beyond weakness of respiratory muscles. MBW with both N

Indexed as

Cystic FibrosisNeuromuscular DiseasesBreath TestsCoughHumansLungAirway clearanceChronic respiratory insufficiencyLung functionPediatric pulmonology

Identifiers

PMID35659287
PMCPMC9166427
OpenAlexW4281754977

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.