Evidence map›Paper›PMID 35659266›Full record

ReviewJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2022

T2 mapping in myocardial disease: a comprehensive review.

Aaron T O'Brien, Katarzyna E Gil, Juliet Varghese, Orlando P Simonetti, Karolina M Zareba

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Persistent Focal MyocardialDiagnostics (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Effect of meal ingestion on parotid gland T2 values.Radiological physics and technology · 2026
    Article
  11. Article
  12. Age-, sex-, and segment-specific myocardial T1 and T2 reference values in a healthy cohort: a prospective single-center study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Field strength dependence, physiologic correlates, and prognostic significance of ventricular blood pool T2 mapping on cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  19. Rosette Cardiac MR Fingerprinting for Simultaneous TMagnetic resonance in medicine · 2026
    Article
  20. Diagnostic and prognostic value of T2 mapping in cardiac sarcoidosis.International journal of cardiology. Heart & vasculature · 2026
    Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Aaron T O'BrienOhio University Heritage College of Osteopathic Medicine, Athens, Ohio, USA.
Katarzyna E GilDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Juliet VargheseDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Orlando P SimonettiDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Karolina M ZarebaDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Karolina.Zareba@osumc.edu.ORCID 0000-0002-4891-4106
The Ohio State University Wexner Medical Center · USOhio University · USThe Ohio State University · US

Funding

Precision Medicine for Dilated Cardiomyopathy-Cardiac Magnetic Resonance to Identify Early Family PhenotypesR01HL148581 · NHLBI · OHIO STATE UNIVERSITY · PI HERSHBERGER, RAY E., KINNAMON, DANIEL DAVIS · 2020 to 2024
$3.2M
Machine learning approach to non-invasive MRI-based blood oximetryR21EB030294 · NIBIB · OHIO STATE UNIVERSITY · PI VARGHESE, JULIET J. · 2021 to 2021
$588k
NHLBI NIH HHS R01 HL148581NIBIB NIH HHS R21 EB030294
6 · The paper itself

Abstract

Cardiovascular magnetic resonance (CMR) is considered the gold standard imaging modality for myocardial tissue characterization. Elevated transverse relaxation time (T2) is specific for increased myocardial water content, increased free water, and is used as an index of myocardial edema. The strengths of quantitative T2 mapping lie in the accurate characterization of myocardial edema, and the early detection of reversible myocardial disease without the use of contrast agents or ionizing radiation. Quantitative T2 mapping overcomes the limitations of T2-weighted imaging for reliable assessment of diffuse myocardial edema and can be used to diagnose, stage, and monitor myocardial injury. Strong evidence supports the clinical use of T2 mapping in acute myocardial infarction, myocarditis, heart transplant rejection, and dilated cardiomyopathy. Accumulating data support the utility of T2 mapping for the assessment of other cardiomyopathies, rheumatologic conditions with cardiac involvement, and monitoring for cancer therapy-related cardiac injury. Importantly, elevated T2 relaxation time may be the first sign of myocardial injury in many diseases and oftentimes precedes symptoms, changes in ejection fraction, and irreversible myocardial remodeling. This comprehensive review discusses the technical considerations and clinical roles of myocardial T2 mapping with an emphasis on expanding the impact of this unique, noninvasive tissue parameter.

Indexed as

CardiomyopathiesMyocarditisContrast MediaEdemaHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMyocardiumPredictive Value of TestsWaterContrast MediaWaterCardiomyopathyMyocardial edemaMyocardial inflammationParametric mappingT2 Mapping

Identifiers

PMID35659266
PMCPMC9167641
OpenAlexW4281638426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.