Evidence map›Paper›PMID 35659227›Full record

SynthesisBMC medical genomics2022

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.

Suzanne Vogelezang, Jonathan P Bradfield, Early Growth Genetics Consortium, Struan F A Grant, Janine F Felix, Vincent W V Jaddoe

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medical genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  5. Article
  6. Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suzanne Vogelezang *The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jonathan P Bradfield *Division of Human Genetics, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Early Growth Genetics Consortium
Struan F A Grant *Division of Human Genetics, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Janine F Felix *The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Vincent W V Jaddoe *The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.

Funding

Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
Integrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7M
Medical Research Council G0600705Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/3NICHD NIH HHS R01 HD056465NIDDK NIH HHS U01 DK105535Wellcome Trust
6 · The paper itself

Abstract

backgroundHead circumference is associated with intelligence and tracks from childhood into adulthood.

methodsWe performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.

resultsSeven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.

conclusionsThe results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

Indexed as

CognitionGenome-Wide Association StudyAdultChildEducational StatusHumansPhenotypeGenetic correlationsGenome-wide association studyHead circumferenceInfancy

Identifiers

PMID35659227
PMCPMC9166310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.