Evidence map›Paper›PMID 35659077›Full record

ReviewSleep medicine clinics2022

Circadian Rhythm Sleep-Wake Disorders in Older Adults.

Jee Hyun Kim, Alexandria R Elkhadem, Jeanne F Duffy

Open access · greenAbstract readReview
In one paragraph

Review in Sleep medicine clinics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. The bidirectional mechanistic links between Alzheimer's disease and cardiovascular disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Age and the Diurnal Oscillatory Features of the Human Chronobiome.medRxiv : the preprint server for health sciences · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jee Hyun KimDepartment of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Gonghangdae-ro 260, Gangseo-gu, Seoul, Republic of Korea.
Alexandria R ElkhademDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Avenue BLI438, Boston, MA 02115, USA.
Jeanne F DuffyDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: jduffy@research.bwh.harvard.edu.
Circadian (United States) · USEwha Womans University · KRHarvard University · US

Funding

TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1991 to 2018
$23.1M
Treatment of Circadian Disruption from Shiftwork in Older AdultsR01AG044416 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DUFFY, JEANNE F · 2013 to 2022
$4.3M
Proteomic and Transcriptomic Biomarkers of Circadian TimingR01HL148704 · NHLBI · STANFORD UNIVERSITY · PI DUFFY, JEANNE F, MIGNOT, EMMANUEL J · 2020 to 2023
$3.4M
NHLBI NIH HHS R01 HL148704NIA NIH HHS P01 AG009975NIA NIH HHS R01 AG044416
6 · The paper itself

Abstract

The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows for wakefulness throughout the day and a long consolidated sleep episode at night. Changes to either the sleep regulatory process or how they interact can result in an inability to fall asleep at the desired time, difficulty remaining asleep, waking too early, and/or difficulty remaining awake throughout the day. This mismatch between the desired timing of sleep and the ability to fall asleep and remain asleep is a hallmark of a class of sleep disorders called the circadian rhythm sleep-wake disorders. In this updated article, we discuss typical changes in the circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep disorders; and how neurologic diseases in older patient impact circadian rhythms and sleep.

Indexed as

MelatoninSleep Disorders, Circadian RhythmSleep Wake DisordersAgedCircadian RhythmHumansSleepWakefulnessMelatoninAdvanced sleep phaseAlzheimer’s diseaseCircadian rhythm disruptionCircadian rhythm sleep disordersDelayed sleep phaseLight therapyMelatonin

Identifiers

PMID35659077
PMCPMC9181175
OpenAlexW4281615835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.