ArticleCardiovascular diabetology2022
Impact of red cell distribution width and red cell distribution width/albumin ratio on all-cause mortality in patients with type 2 diabetes and foot ulcers: a retrospective cohort study.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 91 citations in OpenAlex.
- Association of the red blood cell distribution width-to-albumin ratio with incident depression and depressive symptom trajectories in older adults.European archives of psychiatry and clinical neuroscience · 2026Article
- Comparative Diagnostic Performance of RDW-to-Albumin and CRP-to-Albumin Ratios in Neonatal Sepsis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- [Elevation of red blood cell distribution width to hematocrit ratio is associated with increased 28-day all-cause mortality in septic patients].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Nonlinear relationship between erythrocyte distribution width and albumin ratio and prevalence of gout in adult hypertensive patients.Clinical rheumatology · 2026Article
- Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Stroke Among Adults in the United States.Anatolian journal of cardiology · 2026Article
- The association between the red blood cell distribution width-to-albumin ratio and female infertility: A cross-sectional study.Medicine · 2026Article
- Red cell distribution width: a novel and accessible predictor for immune checkpoint inhibitor-associated myocarditis-a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- The red cell distribution width to albumin ratio as a novel biomarker for predicting short-term mortality in severe pulmonary sepsis: a retrospective study with dual-cohort validation.Frontiers in medicine · 2026Article
- Red Blood Cell Distribution Width-to-Albumin Ratio (RAR) Is an Independent Predictor of Mortality in Non-Anemic Elderly with Hip Fractures.International journal of general medicine · 2026Article
- Red cell distribution width to albumin ratio predicts short-term mortality in urosepsis: a dual-cohort study.Frontiers in nutrition · 2026Article
- Prognostic value of the creatinine-to-albumin ratio for 28-day mortality in patients with sepsis and diabetes: integrating renal and nutritional status in the ICU.Frontiers in nutrition · 2026Article
- RAR and infant mortality: a crucial link in cardiac surgery outcomes.Frontiers in immunology · 2026Observational
- Admission red cell distribution width-to-albumin ratio and risk of neonatal pneumonia or culture-proven sepsis in preterm infants: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Association of novel inflammatory biomarkers with major amputation level in diabetic foot ulcer patients undergoing amputation: a retrospective comparative study.Frontiers in endocrinology · 2026Article
- Red Cell Distribution Width-to-Albumin Ratio as a Predictor of Preeclampsia in Advanced Maternal Age: A Retrospective Cohort Study.International journal of women's health · 2026Article
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- Correlation of red cell distribution width with depression among adults with and without self-reported history of cancer.Scientific reports · 2025Article
- Machine learning models predict mortality risk in diabetic neuropathy patients using MIMIC-IV data.Scientific reports · 2025Article
- Red cell distribution width (RDW), RDW to albumin ratio (RAR), and long-term mortality in diabetic neuropathy: A NHANES analysis, 1999-2019.Journal of diabetes investigation · 2025Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRed blood cell distribution width (RDW) has emerged as a prognostic factor for mortality in various diseases. Up to now, few studies have focused on the prognostic value of RDW in patients with diabetic foot ulcers (DFUs). This retrospective cohort study aimed to investigate the impact of RDW and RDW/albumin (ALB) ratio on all-cause mortality in patients with DFUs.
methodsThis study included 860 patients with DFUs in a tertiary academic hospital. The associations of RDW and RDW/ALB with all-cause mortality were assessed by multivariable cox regression analyses. The pairwise comparisons of receiver operating characteristic (ROC) curves were performed to compare the predictive performance of RDW and RDW/ALB ratio. Harrell's concordance index, integrated discrimination improvement, and net reclassification improvement were used to estimate the improvements in risk discrimination.
resultsPatients with high RDW and RDW/ALB had lower overall survival rates (all P < 0.001). The multivariable Cox regression revealed that high RDW [adjusted hazard ratio (HR) 2.426, 95% confidence interval (CI): 1.557-3.778, P < 0.001] and high RDW/ALB (adjusted HR 2.360, 95% CI: 1.414-3.942, P = 0.001) were independent associated with high all-cause mortality. In subgroup analyses, the comparative analysis of ROC curves revealed that the discriminating ability of the RDW/ALB ratio was significantly superior to RDW in patients with no severe DFUs or no severe peripheral artery disease, or in young and middle-aged patients (all P < 0.05). Adding RDW and RDW/ALB ratio to base models improved discrimination and risk reclassification for all-cause mortality.
conclusionsRDW and RDW/ALB ratio are robust and independent prognostic markers in patients with DFUs. The RDW/ALB ratio appears to be of more predictive value for mortality in younger and less severely ill patients with DFUs. Both RDW and RDW/ALB ratio can provide incremental predictive value for all-cause mortality over traditional risk factors. RDW and RDW/ALB ratio can be used to identify high-risk patients with DFUs.
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