Evidence map›Paper›PMID 35658896›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2022

Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-

Steen Hylgaard Joergensen, Esben Soevsoe S Hansen, Nikolaj Bøgh, Lotte Bonde Bertelsen, Peter Bisgaard Staehr, Rolf F Schulte, Craig Malloy, Henrik Wiggers, Christoffer Laustsen

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Stable electron-irradiated [1-Science advances · 2025
    Article
  4. Hyperpolarized [1-Journal of magnetic resonance open · 2025
    Article
  5. Article
  6. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  7. Review
  8. Review
  9. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  10. Review
  11. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  12. Article
  13. Regional quantification of cardiac metabolism with hyperpolarized [1-Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  14. Article
  15. Regional quantification of cardiac metabolism with hyperpolarized [1-medRxiv : the preprint server for health sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Steen Hylgaard JoergensenDepartment of Clinical Medicine, Aarhus University Hospital, The MR-Research Centre, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark. s.joergensen@rn.dk.ORCID 0000-0002-1146-3882
Esben Soevsoe S HansenDepartment of Clinical Medicine, Aarhus University Hospital, The MR-Research Centre, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Nikolaj BøghDepartment of Clinical Medicine, Aarhus University Hospital, The MR-Research Centre, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Lotte Bonde BertelsenDepartment of Clinical Medicine, Aarhus University Hospital, The MR-Research Centre, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Peter Bisgaard StaehrDepartment of Cardiology, North Denmark Regional Hospital, Bispensgade 37, 9800, Hjoerring, Denmark.
Rolf F SchulteGE Healthcare, Munich, Germany.
Craig MalloyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, USA.
Henrik WiggersDepartment of Clinical Medicine, Department of Cardiology, Aarhus University Hospital, Hjoerring, Denmark.
Christoffer LaustsenDepartment of Clinical Medicine, Aarhus University Hospital, The MR-Research Centre, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Aarhus University Hospital · DKNorth Denmark Region · DKSiemens Healthineers (Germany) · DESouthwestern Medical Center · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
NIBIB NIH HHS P41 EB015908
6 · The paper itself

Abstract

backgroundHyperpolarized (HP) [1-

methodsA prospective descriptive study was performed between October 2019 and August 2020. Healthy human subjects underwent cine CMR and HP [1-

resultsSix healthy subjects (two female), age 29 ± 7 years were studied and no adverse reactions occurred. Myocardial [1-

conclusionsAdenosine stress testing combined with HP [1-

Indexed as

Myocardial Perfusion ImagingPyruvic AcidAdenosineAdultExercise TestFemaleHumansLactatesMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleOxidoreductasesPredictive Value of TestsProspective StudiesYoung AdultAdenosineLactatesOxidoreductasesPyruvic AcidCardiac metabolismMetabolic imagingPerfusionStress test

Identifiers

PMID35658896
PMCPMC9169396
OpenAlexW4282048807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.