Evidence map›Paper›PMID 35658853›Full record

ArticleBMC musculoskeletal disorders2022

Prior use of antibiotics and immunosuppression are risk factors for fracture-related infection during the COVID-19 pandemic period: a Brazilian prospective cohort study.

Eduardo Cezar Santos, Stefânia Prebianchi, Ingrid Nayara Santos, Mariana Neri Kurihara, Adriana Dell'Aquila, Carlos Finelli, Fernando Baldy Dos Reis, Mauro José Salles

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eduardo Cezar SantosDepartment of Orthopedic, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil. eduardocezar.ortopedia@gmail.com.
Stefânia PrebianchiDepartment of Orthopedic, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Ingrid Nayara SantosLaboratório Especial de Microbiologia Clínica (LEMC), Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Mariana Neri KuriharaLaboratório Especial de Microbiologia Clínica (LEMC), Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Adriana Dell'AquilaDepartment of Internal Medicine, Division of infectious Diseases, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Carlos FinelliDepartment of Orthopedic, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Fernando Baldy Dos ReisDepartment of Orthopedic, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Mauro José SallesLaboratório Especial de Microbiologia Clínica (LEMC), Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about the role of COVID-19 pandemic period on the epidemiology of fracture-related infection (FRI). The present study summarizes the changes in the prevalence, microbiology, and risk factors of FRI during this period.

methodsA prospective single-center cohort study assessed in the setting of COVID-19 pandemic (2020-2021), clinical, microbiological aspects, and independent risk factors (RF) of FRI. RFs were estimated by bivariate and multivariable analyses using prevalence ratio (PR) with significance at P < 0.05. Kaplan-Meier analysis was performed to evaluate treatment outcomes.

resultsOverall, 132 patients were analyzed, with patients with age over 65 years accounting 65.1%. FRI was diagnosed in 21(15.9%) patients. Independent RFs for FRI were recent and preoperative use of systemic antibiotics (PR: 7.0, 95% confidence interval (95% CI): 2.2 - 22.4, p = 0.001) and cancer (PR: 9.8, 95% CI: 2.0 - 48.8, p = 0.005). Cultures yielded Gram-negative bacteria in 77.8%, 33.3% were MDR.

conclusionsWe found higher rates of FRI, predominating in the elderly with closed femoral fractures during the COVID-19 pandemic. Prior use of antibiotics and immunosuppression conditions were independent factor for FRI. Our outcomes provide evidence to avoid the empirical use of antibiotics prior to surgery for fracture stabilization.

Indexed as

COVID-19Fractures, BoneAgedAnti-Bacterial AgentsBrazilCohort StudiesHumansImmunosuppression TherapyPandemicsProspective StudiesRisk FactorsAnti-Bacterial AgentsCancerCOVID-19 pandemicElderlyFracture-related infectionGram-negative bacteriaMultidrug-resistancePrior use of antibioticRisk factors

Identifiers

PMID35658853
PMCPMC9166157
OpenAlexW4281708558

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.