Evidence map›Paper›PMID 35658790›Full record

ArticleSmall GTPases2022

An ultra-sensitive method to detect mutations in human

Siqi Li, Christopher M Counter

Open access · bronzeAbstract read
In one paragraph

Article in Small GTPases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Siqi LiDepartment of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Christopher M CounterDepartment of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-0748-3079
Duke Medical Center · USFred Hutch Cancer Center · US

Funding

Project 4: The role of codon bias in RAS tumorigenesisP01CA203657 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 2016 to 2020
$7.9M
RalA signal transductionR01CA094184 · NCI · DUKE UNIVERSITY · PI COUNTER, CHRISTOPHER M · 2002 to 2018
$4.1M
Genetic dissection of oncogenic RAS-driven tumor initiation in vivoR01CA269272 · NCI · DUKE UNIVERSITY · PI CHRISTOPHER M COUNTER · 2022 to 2026
$2.2M
NCI NIH HHS P01 CA203657NCI NIH HHS R01 CA094184NCI NIH HHS R01 CA269272
6 · The paper itself

Abstract

The RAS family of small GTPases is mutated in roughly a fifth of human cancers. Hotspot point mutations at codons G

Indexed as

Genes, rasNeoplasmsAnimalsCarcinogenesisCell Transformation, NeoplasticHumansMiceMutationProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins p21(ras)mutationmutation detectionRASSmall GTPasesultra-sensitive sequencing

Identifiers

PMID35658790
PMCPMC9584555
OpenAlexW4281795735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.