Evidence map›Paper›PMID 35658650›Full record

Trial reportInquiry : a journal of medical care organization, provision and financing

Which Frequency of Ankle Pump Exercise Should Be Chosen for the Prophylaxis of Deep Vein Thrombosis?

Haiyan Li, Wei Zhang, Qingsheng Lu, Jinping Wang, Yanru Zhi, Lingjuan Zhang, Lanshu Zhou

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Inquiry : a journal of medical care organization, provision and financing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07688642 (Boosting Venous Return After Knee Replacement), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07688642 nanot yet recruitingnot on this map

Boosting Venous Return After Knee Replacement: Effects of a Novel Circulatory Exercise on Early Postoperative Inflammation - A Randomized Controlled Trial

TypeinterventionalSponsorAssiut UniversityRan2026 to 2027Enrolled68ConditionsTotal Knee Replacement, Knee Osteoarthritis, Postoperative Edema, Postoperative InflammationArmsstandard postoperative TKR rehabilitation, Standard Rehabilitation Plus Circulatory Exercise
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haiyan LiDepartment of Vascular Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.
Wei ZhangDepartment of Clinical Nursing, Nursing School, Naval Medical University, Shanghai, China.ORCID 0000-0002-0659-9371
Qingsheng LuDepartment of Vascular Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.ORCID 0000-0003-0262-7985
Jinping WangDepartment of Vascular Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.
Yanru ZhiDepartment of Vascular Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.
Lingjuan ZhangEducation and Scientific Research Department of Clinical Nursing, Changhai Hospital Affiliated to Naval Medical University, Shanghai, China.
Lanshu ZhouDepartment of Clinical Nursing, Nursing School, Naval Medical University, Shanghai, China.
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnkle pump exercise (APE) is an effective method to prevent deep vein thrombosis (DVT) in the lower extremities. However, traditional APE at a frequency of 3 times/min applied in the clinic lacked high compliance, and individuals were found to prefer an APE of 30 times/min. This study aimed to compare the effects of APEs with the above two different frequencies on the venous hemodynamics and fatigue of lower extremities.

methodsThe study applied a randomized cross-over design, and 307 healthy adults were randomly assigned into two groups, whose left feet performed 5 minutes of traditional APE (3 times/min, after 10 minutes of rest) and 5 minutes of selected APE (30 times/min, after 10 minutes of rest) in different orders. The diameters and blood flow velocities of the external iliac vein, femoral vein, and popliteal vein of the left extremities were recorded with the color doppler ultrasound when participants were at rest and after 5 minutes of traditional or selected APE. The fatigue of lower extremities was assessed with the Rating of Perceived Exertion (RPE) after the participants performed 5 minutes of different APEs.

resultsAfter both traditional APE and selected APE, the diameters and blood flow (peak systolic) velocities of the external iliac vein, femoral vein, and popliteal vein increased significantly in the participants (P<.01), and the effects of the two APEs on venous hemodynamics of the lower extremities had no significant difference (P>.05). However, participants reported that traditional APE caused higher fatigue, and 252 (82.1%) participants preferred APE at 30 times/min.

conclusionBoth traditional and selected APE could increase venous blood flow in the lower extremity. Despite the equivalent effects, the selected APE of 30 times/min may cause less fatigue than the traditional one of 3 times/min.

Indexed as

AnkleVenous ThrombosisAdultFatigueFemoral VeinHumansIliac Veinankle pump exercisedeep vein thrombosisexercise interventionnursing practicerating of perceived exertion

Identifiers

PMID35658650
PMCPMC9168852
OpenAlexW4282922901

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.