Evidence map›Paper›PMID 35658538›Full record

ArticlemBio2022

Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization.

Lindsey R Burcham, Madeline S Akbari, Norhan Alhajjar, Rebecca A Keogh, Jana N Radin, Thomas E Kehl-Fie, Ashton T Belew, Najib M El-Sayed, Kevin S McIver, Kelly S Doran

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. A murine model of adult gastrointestinal colonization by Group BbioRxiv : the preprint server for biology · 2025
    Article
  7. Identification of glyoxalase A in group BInfection and immunity · 2025
    Article
  8. Article
  9. Identification of Glyoxalase A in Group BbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lindsey R BurchamDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Madeline S AkbariDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Norhan AlhajjarDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Rebecca A KeoghDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jana N RadinDepartment of Microbiology, University of Illinois at Urbana-Champaigngrid.35403.31, Urbana, Illinois, USA.
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois at Urbana-Champaigngrid.35403.31, Urbana, Illinois, USA.ORCID 0000-0001-8234-1113
Ashton T BelewCell Biology and Molecular Genetics, University of Maryland, College Parkgrid.164295.d, Maryland, USA.
Najib M El-SayedCell Biology and Molecular Genetics, University of Maryland, College Parkgrid.164295.d, Maryland, USA.ORCID 0000-0001-7970-3312
Kevin S McIverCell Biology and Molecular Genetics, University of Maryland, College Parkgrid.164295.d, Maryland, USA.ORCID 0000-0002-4769-4463
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-4232-6837
University of Colorado Denver · USUniversity of Maryland, College Park · USUniversity of Illinois Urbana-Champaign · US

Funding

PRD-Containing Virulence Regulators of Pathogenic StreptococciR01AI047928 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MCIVER, KEVIN S. · 2001 to 2023
$6.5M
Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tractR01AI153332 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2021 to 2025
$2.9M
Research Training Program in Metabolism, Obesity and Type 2 DiabetesT32DK120521 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DANIEL Holland BESSESEN · 2020 to 2026
$2.1M
Modulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial MeningitisR01NS116716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2020 to 2024
$1.9M
Calprotectin modulates Group B streptococcal colonization and diseaseR21AI159040 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2021 to 2022
$456k
Role of ScfAB in the Pathophysiology of the Group A StreptococcusR21AI134079 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI MCIVER, KEVIN S. · 2017 to 2018
$418k
NIAID NIH HHS R01 AI047928NIAID NIH HHS R01 AI153332NIAID NIH HHS R21 AI134079NIAID NIH HHS R21 AI159040NIDDK NIH HHS T32 DK120521NINDS NIH HHS R01 NS116716
6 · The paper itself

Abstract

Group B Streptococcus (GBS) is associated with severe infections

Indexed as

ManganeseStreptococcal InfectionsAnimalsFemaleGenomicsHomeostasisHydrogen PeroxideLeukocyte L1 Antigen ComplexMiceParaquatPregnancyStreptococcus agalactiaeVaginaHydrogen PeroxideLeukocyte L1 Antigen ComplexManganeseParaquatGroup B Streptococcusintrauterine infectionmanganesevaginal colonization

Identifiers

PMID35658538
PMCPMC9239048
OpenAlexW4281788058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.