Evidence map›Paper›PMID 35658464›Full record

ArticleCirculation. Heart failure2022

Right Heart Failure Following Left Ventricular Device Implantation: Natural History, Risk Factors, and Outcomes: An Analysis of the STS INTERMACS Database.

Chris J Kapelios, Lars H Lund, Omar Wever-Pinzon, Craig H Selzman, Susan L Myers, Ryan S Cantor, Josef Stehlik, Themistocles Chamogeorgakis, Stephen H McKellar, Antigone Koliopoulou and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  16. Fibrosis 4 Index Predicts Haemocompatibility-Related Adverse Events in Patients Using Left Ventricular Assist Devices.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Chris J KapeliosUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0003-1616-6307
Lars H LundKarolinska University Hospital, Stockholm, Sweden (L.H.L.).ORCID 0000-0003-1411-4482
Omar Wever-PinzonUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0002-2828-707X
Craig H SelzmanUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0001-9218-4764
Susan L MyersKirklin Institute for Research in Surgical Outcomes, University of Alabama at Birmingham (S.L.M., R.S.C., J.K.K.).
Ryan S CantorKirklin Institute for Research in Surgical Outcomes, University of Alabama at Birmingham (S.L.M., R.S.C., J.K.K.).ORCID 0000-0002-3102-2638
Josef StehlikUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0002-7362-0513
Themistocles ChamogeorgakisHenry Ford Health System, Detroit, MI (T.C.).
Stephen H McKellarUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0001-5173-5574
Antigone KoliopoulouUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).
Rami AlharethiIntermountain Medical Center, Salt Lake City, UT (R.A., A.G.K.).
Abdallah G KfouryIntermountain Medical Center, Salt Lake City, UT (R.A., A.G.K.).
Michael BoniosOnassis Cardiac Surgery Center, Athens, Greece (M.B., S.A.).
Stamatis AdamopoulosOnassis Cardiac Surgery Center, Athens, Greece (M.B., S.A.).
Edward M GilbertUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).
James C FangUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0003-2427-9504
James K KirklinKirklin Institute for Research in Surgical Outcomes, University of Alabama at Birmingham (S.L.M., R.S.C., J.K.K.).
Stavros G DrakosUniversity of Utah Health & School of Medicine, Salt Lake City (C.J.K., O.W.-P., C.H.S., J.S., S.H.M., A.K., E.M.G., J.C.F., S.G.D.).ORCID 0000-0002-1223-327X
University of Utah · USKirklin Clinic · USIntermountain Medical Center · USNational and Kapodistrian University of Athens · GROnassis Cardiac Surgery Center · GRHenry Ford Health System · USKarolinska University Hospital · SE

Funding

Clinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9M
Understanding Myocardial Recovery in Diabetes and Heart FailureI01CX002291 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI DRAKOS, STAVROS GEORGE · 2021 to 2025
–
CSRD VA I01 CX002291NHLBI NIH HHS R01 HL135121
6 · The paper itself

Abstract

backgroundOur current understanding of right heart failure (RHF) post-left ventricular assist device (LVAD) is lacking. Recently, a new Interagency Registry for Mechanically Assisted Circulatory Support definition of RHF was introduced. Based on this definition, we investigated natural history, risk factors, and outcomes of post-LVAD RHF.

methodsPatients implanted with continuous flow LVAD between June 2, 2014, and June 30, 2016 and registered in the Interagency Registry for Mechanically Assisted Circulatory Support/Society of Thoracic Surgeons Database were included. RHF incidence and predictors, and survival after RHF were assessed. The manifestations of RHF which were separately analyzed were elevated central venous pressure, peripheral edema, ascites, and use of inotropes.

resultsAmong 5537 LVAD recipients (mean 57±13 years, 49% destination therapy, support 18.9 months) prevalence of 1-month RHF was 24%. Of these, RHF persisted at 12 months in 5.3%. In contrast, de novo RHF, first identified at 3 months, occurred in 5.1% and persisted at 12 months in 17% of these, and at 6 months occurred in 4.8% and persisted at 12 months in 25%. Higher preimplant blood urea nitrogen (ORs,1.03-1.09 per 5 mg/dL increase;

conclusionsRHF at 1 or 3 months post-LVAD was a common and frequently transient condition, which, if resolved, was associated with relatively favorable prognosis. Conversely, de novo, late RHF post-LVAD (>6 months) was more frequently a persistent disorder and associated with increased mortality. The 1-, 3-, and 6-month time points may be used for RHF assessment and risk stratification in LVAD recipients.

Indexed as

Heart-Assist DevicesHeart FailureHeart VentriclesHumansRegistriesRetrospective StudiesRisk FactorsTreatment Outcomeedemaheart failurehepatomegalyprevalenceprognosis

Identifiers

PMID35658464
PMCPMC9233112
OpenAlexW4282933050

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.