ArticlePloS one2022
Heat stress modulates the disruptive effects of Eimeria maxima infection on the ileum nutrient digestibility, molecular transporters, and tissue morphology in meat-type chickens.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
- L-cysteine enhances heat-stress adaptation in meat-type chickens through modulation of cysteine-metabolic and nutrient transporter genes.Poultry science · 2026Article
- Exploring the interplay betweenThe veterinary quarterly · 2025Review
- Effects of Antimicrobial Peptides on the Growth Performance of Squabs Were Investigated Based on Microbiomics and Non-Targeted Metabolomics.Animals : an open access journal from MDPI · 2025Article
- Impact of Temperature Variations on the Viability and Infectivity of Sporulated Eimeria papillata Oocysts in C57BL/6 Mice.Current microbiology · 2025Article
- Effects of microencapsulated essential oils and seaweed meal on growth performance, digestive enzymes, intestinal morphology, liver functions, and plasma biomarkers in broiler chickens.Journal of animal science · 2025Article
- Article
- Changes in rectal temperature as a means of assessing heat tolerance and sensitivity in chickens.Tropical animal health and production · 2024Article
- Eimeria: Navigating complex intestinal ecosystems.PLoS pathogens · 2024Review
- Host transcriptome response to heat stress and Eimeria maxima infection in meat-type chickens.PloS one · 2024Article
- Glucose Supplementation Improves Performance and Alters Glucose Transporters' Expression inAnimals : an open access journal from MDPI · 2023Article
- Effects of DifferentAnimals : an open access journal from MDPI · 2023Article
- Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eimeria (E.) maxima is one of the most pathogenic Eimeria spp persistently invading the middle jejunum and ileum, damaging the intestinal mucosa of chickens. Heat stress (HS) is a common stressor and equally contributes to inflammation and oxidative stress. We investigated the effect of E. maxima infection and HS on ileal digestibility, mRNA expression of nutrient transporters, and ileal tissue morphology in broiler chickens. There were four treatment groups: thermoneutral control (TNc), thermoneutral infected (TNi), heat stress control (HSc), and heat stress infected (HSi), 6 replicates each of 10 birds per treatment. Chickens were fed a diet containing 0.2% TiO2. At 6-day-post infection, ileal content and tissue were collected to quantify ileal digestibility of crude protein and fat, mRNA levels of nutrient transporters and histopathology. Growth and feed intake were reduced in all treatment groups, compared with the TNc. Contrary to expectation, the combination of two major stressors (E. maxima and HS) in the TNi group exhibited almost normal digestibility while only the TNi birds expressed severe digestibility depression, compared with the TNc group. The TNi group showed the lowest mRNA expression of the transporters: SGLT1, GLUT2-5-8-10-12, FABP1-2-6, and PEPT1 compared with the other treatment groups. The expression of the absorptive enterocytes' gene markers (ACSL5, IAP, and SGLT1) supported by the ileal tissue morphology indicated that the TNi group had the highest enterocytic destruction. The expression of oxidative genes (iNOS and CYBB) dramatically increased only in the TNi group compared with the other treatment groups. Our results showed that exposing broiler chickens to HS can mitigate the disruptive effect of E. maxima on the ileal digestibility and absorption by limiting the parasite-induced tissue injury and suppressing the enterocytic inducible oxidative damage.
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