Evidence map›Paper›PMID 35657810›Full record

ArticlePloS one2022

Correlation between genetic and environmental risk factors for age-related macular degeneration in Brazilian patients.

Priscila H H Rim, José Paulo C de Vasconcellos, Mônica B de Melo, Flavio M C Medina, Daniela P D Sacconi, Tamires P Lana, Fabio E Hirata, Luis A Magna, Antonia P Marques-de-Faria

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Priscila H H RimDepartment of Ophthalmology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID 0000-0002-6046-6377
José Paulo C de VasconcellosDepartment of Ophthalmology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Mônica B de MeloLaboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Flavio M C MedinaDepartment of Ophthalmology, School of Medical Sciences, Rio de Janeiro State University (UERJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Daniela P D SacconiLaboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Tamires P LanaLaboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Fabio E HirataDepartment of Ophthalmology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Luis A MagnaDepartment of Medical Genetics, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Antonia P Marques-de-FariaDepartment of Medical Genetics, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the correlations between age-related macular degeneration (AMD) and genetic and environmental risk factors for in a Brazilian population.

designCross-sectional study with a control group.

methodsWe collected data on 236 participants 50 years of age or older (141 with AMD and 95 controls without the disease). Data was obtained using a questionnaire and included information on demographics, ocular and medical history, family history of AMD, lifestyle, and smoking and drinking habits. Genetic evaluations included direct sequencing for the LOC387715 (rs10490924) variant, as well as PCR and enzymatic digestion for the CFH Y402H (rs1061170) and HTRA1 (rs11200638) variants. We performed a risk assessment of environmental risk factors and genetic variants associated with AMD and determined correlations between AMD and the data collected using multiple linear regression analysis.

resultsOf the 141 AMD cases, 99 (70%) had advanced AMD in at least one eye (57% neovascular AMD and 13% geographic atrophy), and 42 (30%) had not-advanced AMD. Family history of AMD (OR: 6.58; 95% CI: 1.94-22.31), presence of cardiovascular disease (CVD) (OR: 2.39; 95% CI: 1.08-5.28), low physical activity level (OR: 1.39; 95% CI: 0.82-2.37), and high serum cholesterol (OR: 1.49; 95% CI: 0.84-2.65) were associated with an increased risk for AMD. There was a significant association between CVD and incidence of advanced AMD (OR: 2.29; 95% CI 0.81-6.44). The OR for the risk allele of the LOC387715 gene, the CFH gene and the HTRA1 gene were 2.21 (95% CI: 1.47-3.35), 2.27 (95% CI: 1.52-3.37), and 2.76 (95% CI: 1.89-4.03), respectively. In the stepwise multiple linear regression analyses, the HTRA1 and CFH risk alleles, family history of AMD, the LOC387715 risk allele, and CVD were associated with an increased risk of AMD for a total of 25.6% contribution to the AMD phenotype.

conclusionsThe analysis correlating environmental and genetic risk factors such as family history of AMD, and CVD and the variants of HTRA1, CFH, and LOC387715 genes showed an expressive contribution for the development of AMD among this admixed population.

Indexed as

Cardiovascular DiseasesWet Macular DegenerationAngiogenesis InhibitorsBrazilComplement Factor HCross-Sectional StudiesGenotypeHigh-Temperature Requirement A Serine Peptidase 1HumansPolymorphism, Single NucleotideRisk FactorsSerine EndopeptidasesVascular Endothelial Growth Factor AVisual AcuityAngiogenesis InhibitorsComplement Factor HHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanSerine EndopeptidasesVascular Endothelial Growth Factor A

Identifiers

PMID35657810
PMCPMC9165864
OpenAlexW4281631587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.