SynthesisPloS one2022
Heart rate variability in hypothyroid patients: A systematic review and meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Changes of cardiac function: cardiac adaptation in patients with hypothyroidism assessed by cardiac magnetic resonance-a meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Enhancing Quality of Life in Patients With Hypothyroidism Using a Scientific Yoga Module: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Elevated blood pressure variability links cardiac autonomic dysfunction to complex arrhythmias in hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Associations of Poincaré Plot-Derived Parameters with Heart Rate Variability and Autonomic Reflex Testing in a Real-World Clinical Population.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation and correlation of heart rate variability and ventricular repolarization parameters in an Indian pediatric clinical hypothyroid population: a prospective cohort study.Scientific reports · 2026Article
- Impact of Thyroid Hormone Imbalance on Electrocardiographic Parameters: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Predictive Value of Heart Rate Variability for Postoperative Atrial Fibrillation in Off-Pump Coronary Artery Bypass Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Article
- Elevated Serum TSH Levels and TPOAb Positivity in Early Pregnancy are Associated with Increased Risk of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study.International journal of medical sciences · 2025Article
- Unveiling the hidden: acquired pediatric hypothyroidism.Frontiers in endocrinology · 2025Review
- Hypothyroidism and Heart Rate Variability: Implications for Cardiac Autonomic Regulation.Diagnostics (Basel, Switzerland) · 2024Article
- Prenatal fluoride exposure, offspring visual acuity and autonomic nervous system function in 6-month-old infants.Environment international · 2024Article
- Effect of the Marine Exercise Retreat Program on Thyroid-Related Hormones in Middle-Aged Euthyroid Women.International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypothyroidism may be associated with changes in the autonomic regulation of the cardiovascular system, which may have clinical implications.
objectiveTo conduct a systematic review and meta-analysis on the impact of hypothyroidism on HRV. MATERIALS AND
methodsPubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hypothyroidism and healthy controls. Random-effects meta-analysis were stratified by degree of hypothyroidism for each HRV parameters: RR intervals (or normal to normal-NN intervals), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50ms variation), total power (TP), LFnu (low-frequency normalized unit), HFnu (high-frequency), VLF (very low frequency), and LF/HF ratio.
resultsWe included 17 studies with 11438 patients: 1163 hypothyroid patients and 10275 healthy controls. There was a decrease in SDNN (effect size = -1.27, 95% CI -1.72 to -0.83), RMSSD (-1.66, -2.32 to -1.00), pNN50 (-1.41, -1.98 to -0.84), TP (-1.55, -2.1 to -1.00), HFnu (-1.21, -1.78 to -0.63) with an increase in LFnu (1.14, 0.63 to 1.66) and LF/HF ratio (1.26, 0.71 to 1.81) (p <0.001). HRV alteration increased with severity of hypothyroidism.
conclusionsHypothyroidism is associated with a decreased HRV, that may be explained by molecular mechanisms involving catecholamines and by the effect of TSH on HRV. The increased sympathetic and decreased parasympathetic activity may have clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.