Evidence map›Paper›PMID 35657670›Full record

ArticleSubstance abuse2022

Opioid use disorder Cascade of care framework design: A roadmap.

Arthur Robin Williams, Kimberly A Johnson, Cindy Parks Thomas, Sharon Reif, M Eugenia Socías, Brandy F Henry, Charles Neighbors, Adam J Gordon, Constance Horgan, Bohdan Nosyk and 9 more

Open access · greenAbstract read
In one paragraph

Article in Substance abuse, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  9. Medicaid health home design and buprenorphine receipt, 2009-2020.Journal of substance use and addiction treatment · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Arthur Robin WilliamsDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-7380-6203
Kimberly A JohnsonUniversity of Southern Florida, Tampa, Florida, USA.ORCID 0000-0002-2179-5688
Cindy Parks ThomasBrandeis University Schneider Institutes for Health Policy, Brandeis, Massachusetts, USA.
Sharon ReifBrandeis University Schneider Institutes for Health Policy, Brandeis, Massachusetts, USA.
M Eugenia SocíasDepartment of Medicine, University of British Columbia, British Columbia, Canada.
Brandy F HenryPennsylvania State University, State College, Pennsylvania, USA.ORCID 0000-0002-0667-9283
Charles NeighborsNew York University, New York City, New York, USA.
Adam J GordonDivision of Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0002-2453-8871
Constance HorganBrandeis University Schneider Institutes for Health Policy, Brandeis, Massachusetts, USA.
Bohdan NosykCentre for Health Evaluation & Outcome Sciences, Faculty of Health Sciences, Simon Fraser University, British Columbia, Canada.
Karen DrexlerAmerican Academy of Addiction Psychiatry, East Providence, Rhode Island, USA.
Noa KrawczykNew York University, New York City, New York, USA.ORCID 0000-0002-7396-3938
Gregg S GonsalvesYale University, New Haven, Connecticut, USA.ORCID 0000-0002-5789-9841
Scott E HadlandMassachusetts General Hospital, Harvard University, Cambridge, Massachusetts, USA.
Bradley D SteinRAND Institute, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1544-458X
Marc FishmanMountain Manor Treatment Centers, Baltimore, Maryland, USA.
A Taylor KelleyDivision of General Internal Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0003-0462-4737
Harold A PincusDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York, USA.
Mark OlfsonDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York, USA.
Brandeis University · USColumbia University Irving Medical Center · USNew York University · USUniversity of Utah · USHarvard University · USPennsylvania State University · USProvidence College · USRAND Corporation · USSimon Fraser University · CAUniversity of British Columbia · CAYale University · US

Funding

Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
Novel, Adaptive Approaches to Predicting and Responding to Outbreaks of Overdose, HIV and HCV Among People Who Use DrugsDP2DA049282 · NIDA · YALE UNIVERSITY · PI GONSALVES, GREGG STEVEN · 2019 to 2019
$2.5M
Improving the treatment cascade of MAT initiation and retention for opioid use disorderK23DA044342 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WILLIAMS, ARTHUR R · 2017 to 2021
$981k
NIDA NIH HHS DP2 DA049282NIDA NIH HHS K23 DA044342NIDA NIH HHS T32 DA037801
6 · The paper itself

Abstract

Unintentional overdose deaths, most involving opioids, have eclipsed all other causes of US deaths for individuals less than 50 years of age. An estimated 2.4 to 5 million individuals have opioid use disorder (OUD) yet a minority receive treatment in a given year. Medications for OUD (MOUD) are the gold standard treatment for OUD however early dropout remains a major challenge for improving clinical outcomes. A Cascade of Care (CoC) framework, first popularized as a public health accountability strategy to stem the spread of HIV, has been adapted specifically for OUD. The CoC framework has been promoted by the NIH and several states and jurisdictions for organizing quality improvement efforts through clinical, policy, and administrative levers to improve OUD treatment initiation and retention. This roadmap details CoC design domains based on available data and potential linkages as individual state agencies and health systems typically rely on limited datasets subject to diverse legal and regulatory requirements constraining options for evaluations. Both graphical decision trees and catalogued studies are provided to help guide efforts by state agencies and health systems to improve data collection and monitoring efforts under the OUD CoC framework.

Indexed as

BuprenorphineDrug OverdoseOpioid-Related DisordersAnalgesics, OpioidHumansOpiate Substitution TreatmentPublic HealthAnalgesics, OpioidBuprenorphineOpioid use disorder; cascade of care; medication for opioid use disorder (MOUD); opioid crisis

Identifiers

PMID35657670
PMCPMC9577537
OpenAlexW4281684428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.