ReviewAmerican journal of physiology. Heart and circulatory physiology2022
Myocardial mesostructure and mesofunction.
Review in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Physics-Informed Reconstruction of Transmural Myocardial Deformation from 3D Echocardiography: Validation Against Cardiac MRI.Annals of biomedical engineering · 2026Article
- Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart.Nature biomedical engineering · 2026Article
- Quantifying Regional and Age-Dependent Microstructural Changes in Porcine Ventricles from Neonatal to Adulthood Using DT-MRI and TPEF-SHG Microscopy.Annals of biomedical engineering · 2026Article
- The Effect of Voxel Volume and Voxel Shape on Cardiac Diffusion Tensor Imaging Metrics.Magnetic resonance in medicine · 2026Article
- Prospective evaluation of speckle-tracking echocardiography for detecting functionally significant coronary artery disease: a quantitative flow ratio-based study.Quantitative imaging in medicine and surgery · 2026Article
- Heart Failure with Preserved Ejection Fraction (HFpEF), Pulse Wave Velocity, and Heart Rate Recovery Interconnections-A Brief Literature Review.Journal of clinical medicine · 2025Review
- Noninvasive assessment of hemodynamic profile and myocardial mechanics in pulsus alternans patients by multiple echocardiographic methods.The ultrasound journal · 2025Article
- Heart in a knot: unraveling the impact of the nested tori myofiber architecture on ventricular mechanics.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- Diffusion tensor imaging reveals myocardial architectural differences between porcine and primate hearts with potential implications for cardiac xenotransplantation.Scientific reports · 2025Article
- The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025Review
- Modelling neurocardiac physiology and diseases using human pluripotent stem cells: current progress and future prospects.The Journal of physiology · 2025Review
- Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue.Photoacoustics · 2025Article
- Multi-center investigation of cardiac diffusion tensor imaging in healthy volunteers by the Society of Cardiovascular Magnetic Resonance Cardiac Diffusion Special Interest Group NETwork (SIGNET).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Observational
- Light-Sheet Imaging to Reveal Cardiac Structure in Rodent Hearts.Journal of visualized experiments : JoVE · 2024Article
- Collagenase treatment reduces the anisotropy of ultrasonic backscatter in rat myocardium by reducing collagen crosslinks.Physiological reports · 2023Article
- Effects of myocardial sheetlet sliding on left ventricular function.Biomechanics and modeling in mechanobiology · 2023Article
- Myocardial Segmentation of Tagged Magnetic Resonance Images with Transfer Learning Using Generative Cine-To-Tagged Dataset Transformation.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The complex and highly organized structural arrangement of some five billion cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the human heart. The characteristic transmural change in cardiomyocyte orientation underlies base-to-apex shortening, circumferential shortening, and left ventricular torsion during contraction. Individual cardiomyocytes shorten ∼15% and increase in diameter ∼8%. Remarkably, however, the left ventricular wall thickens by up to 30-40%. To accommodate this, the myocardium must undergo significant structural rearrangement during contraction. At the mesoscale, collections of cardiomyocytes are organized into sheetlets, and sheetlet shear is the fundamental mechanism of rearrangement that produces wall thickening. Herein, we review the histological and physiological studies of myocardial mesostructure that have established the sheetlet shear model of wall thickening. Recent developments in tissue clearing techniques allow for imaging of whole hearts at the cellular scale, whereas magnetic resonance imaging (MRI) and computed tomography (CT) can image the myocardium at the mesoscale (100 µm to 1 mm) to resolve cardiomyocyte orientation and organization. Through histology, cardiac diffusion tensor imaging (DTI), and other modalities, mesostructural sheetlets have been confirmed in both animal and human hearts. Recent in vivo cardiac DTI methods have measured reorientation of sheetlets during the cardiac cycle. We also examine the role of pathological cardiac remodeling on sheetlet organization and reorientation, and the impact this has on ventricular function and dysfunction. We also review the unresolved mesostructural questions and challenges that may direct future work in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.