Evidence map›Paper›PMID 35657483›Full record

ReviewCurrent oncology reports2022

The Evolving Therapeutic Landscape for Malignant Pleural Mesothelioma.

Nirosha D Perera, Aaron S Mansfield

Open access · greenAbstract readReview
In one paragraph

Review in Current oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. [Recent Advances in Medical Treatment of Malignant Pleural Mesothelioma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
    Review
  8. Review
  9. Recurrent Tumor Suppressor Alterations in Primary Pericardial Mesothelioma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nirosha D PereraDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0001-5031-9579
Aaron S MansfieldDivision of Medical Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA. mansfield.aaron@mayo.edu.ORCID 0000-0002-9483-6903
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

Blood-based biomarker of therapeutic efficacy for mesotheliomaR21CA251923 · NCI · MAYO CLINIC ROCHESTER · PI MANSFIELD, AARON SCOTT · 2020 to 2020
$409k
NCI NIH HHS R21 CA251923
6 · The paper itself

Abstract

purpose of reviewFor patients with malignant pleural mesothelioma, prognosis is poor with extremely low 5-year survival rates and limited therapeutic options. Here, we review the current treatment landscape for mesothelioma and highlight promising future therapeutic directions. RECENT

findingsEvolving frontline therapeutic options for mesothelioma include VEGF inhibition in combination with chemotherapy and dual immune checkpoint inhibition, with synergisms between the therapies and response prediction via biomarkers also being explored. Evolving experimental treatments for mesothelioma include PARP and ALK inhibitors, dendritic and CAR T-cell therapies, anti-mesothelin vaccines, and oncolytic viral therapies, representing timely advances in the field. The therapeutic landscape for malignant pleural mesothelioma is evolving and preferred treatment in the frontline and later settings will likely evolve with it. However, this does not preclude the evidence for including multi-modal therapies spanning angiogenesis and immune checkpoint inhibitors, and biomarker utilization, in current clinical trials and management.

Indexed as

Lung NeoplasmsMesotheliomaMesothelioma, MalignantPleural NeoplasmsHumansImmune Checkpoint InhibitorsImmunotherapyPoly(ADP-ribose) Polymerase InhibitorsReceptor Protein-Tyrosine KinasesVascular Endothelial Growth Factor AImmune Checkpoint InhibitorsPoly(ADP-ribose) Polymerase InhibitorsReceptor Protein-Tyrosine KinasesVascular Endothelial Growth Factor ACAR T-cell therapyGenetic targetsImmunotherapyMalignant pleural mesotheliomaMesothelioma biomarkersVEGF inhibition

Identifiers

PMID35657483
PMCPMC9613518
OpenAlexW4281662435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.