Evidence map›Paper›PMID 35657452›Full record

ArticleMolecular biology reports2022

Phenotypic and molecular characterization of extended-spectrum β-lactamase/AmpC- and carbapenemase-producing Klebsiella pneumoniae in Iran.

Forough Babazadeh, Roghayeh Teimourpour, Mohsen Arzanlou, Hadi Peeridogaheh, Mehdi Yousefipour, Jafar MohammadShahi

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Forough BabazadehDepartment of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Roghayeh TeimourpourDepartment of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. r.teymourpour@gmail.com.
Mohsen ArzanlouDepartment of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Hadi PeeridogahehDepartment of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Mehdi YousefipourDepartment of Infectious and Tropical Diseases, Tehran University of Medical Sciences, Tehran, Iran.
Jafar MohammadShahiDepartments of Infectious Diseases, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. j.mohammadshahi@arums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of the current study is to evaluate the phenotypic and molecular characterization of ESBL/AmpC- and carbapenemase-producing K. pneumoniae isolates in Iran.

methodsFrom October 2018 until the end of April 2020, different clinical samples were collected and K. pneumoniae isolates were identified using conventional biochemical tests and PCR assay. Antibiotic susceptibility pattern was determined using the Kirby-Bauer disk diffusion method. Modified Hedge Test (MHT) was applied to the identification of carbapenemase-producing K. pneumoniae. ESBL and AmpC-producing K. pneumoniae were detected using Double Disc Test (DDT) and Disc Potentiation Test (DPT), respectively. The presence of carbapenemase, ESBL, and AmpC encoding genes was screened by Polymerase Chain Reaction (PCR) assay.

resultsA total of 100 K. pneumoniae isolates were collected. K. pneumoniae isolates had the highest resistance rate to cefazolin (66%) and cefotaxime (66%). Meropenem and amikacin with sensitivity rates of 76% and 69% were the most effective antimicrobial agents on K. pneumoniae isolates. It was found that 12 (12%), 27 (27%), and 9 (9%) K. pneumoniae isolates were positive in MHT, DDT, and DPT tests, respectively. Among the carbapenemase-encoding genes, bla

conclusionsIt is vital to adopt effective control strategies for K. pneumoniae infections and ensure rapid identification of antibiotic resistance profile.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesIranMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseAmpCCarbapenemaseEnterobacteriaceaeESBLIranKlebsiella pneumoniae

Identifiers

PMID35657452

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