Evidence map›Paper›PMID 35657402›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

The impact of COVID-19 on autologous stem cell transplantation in multiple myeloma: A single-centre, qualitative evaluation study.

Marquita Camilleri, Georgios Bekris, Govundeep Sidhu, Caroline Buck, Esma Elsden, Orla McCourt, Jackie Horder, Fiona Newrick, Catherine Lecat, Jonathan Sive and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Marquita CamilleriUniversity College Hospital Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK. marquita.camilleri@ucl.ac.uk.ORCID http://orcid.org/0000-0002-4161-8275
Georgios BekrisDepartment of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Govundeep SidhuDepartment of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Caroline BuckDepartment of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Esma ElsdenDepartment of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Orla McCourtUniversity College Hospital Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Jackie HorderHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Fiona NewrickHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Catherine LecatUniversity College Hospital Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Jonathan SiveHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Xenofon PapanikolaouHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Rakesh PopatHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Lydia LeeHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Ke XuHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Charalampia KyriakouHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Neil RabinHaematology Department, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.
Kwee YongUniversity College Hospital Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Abigail FisherDepartment of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
University College London Hospitals NHS Foundation Trust · GBUniversity College London · GBUniversity College Hospital · GB

Funding

Medical Research Council MR/S001883/1
6 · The paper itself

Abstract

Autologous stem cell transplantation (ASCT) is standard of care in biologically fit, newly diagnosed multiple myeloma (MM) patients, offering better therapeutic outcomes and improved quality of life (QoL). However, with the UK's 1st national lockdown on 23/03/2020, several guidelines recommended deferring ASCT due to risks of infection, with resource limitations forcing some units to suspend ASCT entirely. Such changes to patients' treatment plans inevitably altered their lived experience during these uncertain times with expected impact on QoL. We conducted a qualitative study using semi-structured interviews to gain insight into MM patients' understanding of their disease, initial therapy and ASCT, and their response to therapy changes. A clinical snapshot of how COVID-19 affected the MM ASCT service in a single UK institution is also provided, including changes to chemotherapy treatment plans, timing, and prioritisation of ASCT. Framework analysis identified 6 overarching themes: (1) beliefs about ASCT, (2) perceptions of information provided about MM and ASCT, (3) high levels of fear and anxiety due to COVID-19, (4) feelings about ASCT disruption or delay due to COVID-19, (5) perceptions of care, and (6) importance of social support. Example subthemes were beliefs that ASCT would provide a long-remission/best chance of normality including freedom from chemotherapy and associated side-effects, disappointment, and devastation at COVID-related treatment delays (despite high anxiety about infection) and exceptionally high levels of trust in the transplant team. Such insights will help us adjust our service and counselling approaches to be more in tune with patients' priorities and expectations.

Indexed as

COVID-19Hematopoietic Stem Cell TransplantationMultiple MyelomaAntineoplastic Combined Chemotherapy ProtocolsCommunicable Disease ControlHumansQuality of LifeRetrospective StudiesStem Cell TransplantationTransplantation, AutologousAutologous stem cell transplantationCOVID-19Multiple myeloma

Identifiers

PMID35657402
PMCPMC9163289
OpenAlexW4281773509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.