ArticleAngewandte Chemie (International ed. in English)2022
Enantioselective Hydrocarbamoylation of Alkenes.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.Journal of the American Chemical Society · 2025Article
- A general approach to stereospecific Pd-catalyzed cross-coupling reactions of benzylic stereocenters.Chemical science · 2023Article
- Modular access to alkylgermanes via reductive germylative alkylation of activated olefins under nickel catalysis.Nature communications · 2023Article
- Ruthenium(II)/Imidazolidine Carboxylic Acid-Catalyzed C-H Alkylation for Central and Axial Double Enantio-Induction.Angewandte Chemie (International ed. in English) · 2022Article
- Enantioselective Hydrocarbamoylation of Alkenes.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The asymmetric hydroaminocarbonylation of olefins represents a straightforward approach for the synthesis of enantioenriched amides, but is hampered by the necessity to employ CO gas, often at elevated pressures. We herein describe, as an alternative, an enantioselective hydrocarbamoylation of alkenes leveraging dual copper hydride and palladium catalysis to enable the use of readily available carbamoyl chlorides as a practical carbamoylating reagent. The protocol is applicable to various types of olefins, including alkenyl arenes, terminal alkenes, and 1,1-disubstituted alkenes. Substrates containing a diverse range of functional groups as well as heterocyclic substructures undergo functionalization to provide α- and β-chiral amides in good yields and with excellent enantioselectivities.
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Registered trials
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