Evidence map›Paper›PMID 35657158›Full record

ReviewThe Prostate2022

Genomic biomarkers to guide precision radiotherapy in prostate cancer.

Philip Sutera, Matthew P Deek, Kim Van der Eecken, Alexander W Wyatt, Amar U Kishan, Jason K Molitoris, Matthew J Ferris, M Minhaj Siddiqui, Zaker Rana, Mark V Mishra and 6 more

Open access · greenAbstract readReview
In one paragraph

Review in The Prostate, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Prognostic utility of biopsy-basedFrontiers in oncology · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Philip SuteraDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Matthew P DeekDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
Kim Van der EeckenDepartment of Pathology, Ghent University Hospital, Cancer Research Institute (CRIG), Ghent, Belgium.
Alexander W WyattDepartment of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Amar U KishanDepartment of Radiation Oncology, UCLA, Los Angeles, California, USA.
Jason K MolitorisDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Matthew J FerrisDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
M Minhaj SiddiquiDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zaker RanaDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mark V MishraDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Young KwokDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Elai DavicioniVeracyte, San Diego, California, USA.
Daniel E SprattDepartment of Radiation Oncology, University Hospitals, Cleveland, Ohio, USA.
Piet OstDepartment of Radiation Oncology, Iridium Network, Antwerp, Belgium.
Felix Y FengDepartments of Radiation Oncology, Medicine and Urology, UCSF, San Francisco, California, USA.
Phuoc T TranDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0147-0376
University of Maryland, Baltimore · USGhent University Hospital · BEJohns Hopkins University · USRutgers, The State University of New Jersey · USUniversity Hospitals of Cleveland · USUniversity of British Columbia · CAUniversity of California, San Francisco · USVeracyte (United States) · US

Funding

Tumor-barcoding coupled with high-throughput sequencing of a novel chemoradiation resistant SCLC mouse modelU01CA231776 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANN, CHRISTINE L., MARCHIONNI, LUIGI · 2018 to 2022
$3.9M
Integrating bioinformatics into multiscale models for hepatocellular carcinomaU01CA212007 · NCI · JOHNS HOPKINS UNIVERSITY · PI EWALD, ANDREW JOSEF, FERTIG, ELANA · 2018 to 2022
$3.2M
NCI NIH HHS U01 CA212007NCI NIH HHS U01 CA231776NIH HHS U01CA212007NIH HHS U01CA231776
6 · The paper itself

Abstract

Our ability to prognosticate the clinical course of patients with cancer has historically been limited to clinical, histopathological, and radiographic features. It has long been clear however, that these data alone do not adequately capture the heterogeneity and breadth of disease trajectories experienced by patients. The advent of efficient genomic sequencing has led to a revolution in cancer care as we try to understand and personalize treatment specific to patient clinico-genomic phenotypes. Within prostate cancer, emerging evidence suggests that tumor genomics (e.g., DNA, RNA, and epigenetics) can be utilized to inform clinical decision making. In addition to providing discriminatory information about prognosis, it is likely tumor genomics also hold a key in predicting response to oncologic therapies which could be used to further tailor treatment recommendations. Herein we review select literature surrounding the use of tumor genomics within the management of prostate cancer, specifically leaning toward analytically validated and clinically tested genomic biomarkers utilized in radiotherapy and/or adjunctive therapies given with radiotherapy.

Indexed as

Prostatic NeoplasmsBiomarkers, TumorClinical Decision-MakingGenomicsHumansMalePrognosisBiomarkers, Tumorbiomarkersgenomicsprostate cancerradiotherapy

Identifiers

PMID35657158
PMCPMC9202472
OpenAlexW4281750849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.