Evidence map›Paper›PMID 35657004›Full record

ArticleJournal of breast cancer2022

The Association Between Smoking Status and Breast Cancer Recurrence: A Systematic Review.

Muna Alkhaifi, Adam Clayton, Teruko Kishibe, Jory S Simpson

Abstract read
In one paragraph

Article in Journal of breast cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Breast cancer diagnosis as a window of opportunity for smoking cessation: analysis of changes in smoking behaviour in 736 smoking breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muna AlkhaifiDepartment of Family and Community Medicine, St. Michael's Hospital, Unity Health Toronto, Faculty of Medicine, University of Toronto, Toronto, Canada. Muna.al.khaifi@mail.utoronto.ca.ORCID https://orcid.org/0000-0001-8387-7075
Adam ClaytonFaculty of Medicine, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0002-8200-3517
Teruko KishibeLibrary Services, St. Michael Hospital, Unity Health Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0001-8797-7137
Jory S SimpsonDivision of General Surgery, Department of Surgery, St. Michael's Hospital, Unity Health Toronto, Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0002-7864-4207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether smoking status (active/passive) affects recurrence events after breast cancer (BC) diagnosis among women.

methodsA comprehensive literature search of MEDLINE, Cochrane Central, EMBASE, and Web of Science databases on smoking status and BC outcomes retrieved 5,940 articles. After reviewing the inclusion and exclusion criteria, we selected 14 articles for a full review and synthesis.

resultsFive studies were cohort retrospective, 6 were case-control, 2 were prospective cohort studies, and 1 was a secondary analysis of a randomized control trial. Among the 8 articles that focused on active smoking, 6 showed an increased risk of BC recurrence, and 2 showed no evidence of such an association. Studies that examined former smokers found little evidence of an increased risk of BC recurrence. This association may be dose-dependent.

conclusionGiven the current evidence, although limited, active smokers should quit smoking after BC diagnosis as trends indicate a positive association between active smoking and BC recurrence. More robust evidence is needed to assess such associations and examine the outcomes of quitting smoking in such patients.

Indexed as

Breast NeoplasmsRecurrenceSmokingTobacco

Identifiers

PMID35657004
PMCPMC9411030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.