Evidence map›Paper›PMID 35657002›Full record

ArticleJournal of breast cancer2022

Disparities in Access to Systemic Treatment for Breast Cancer in Thailand and Major Asian Territories.

Suthinee Ithimakin, Napa Parinyanitikul, Sung-Bae Kim, Yoon-Sim Yap, Janice Tsang, Inda S Soong, Yukinori Ozaki, Shinji Ohno, Makiko Ono, Jack Junjie Chan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of breast cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 9 countries.

Suthinee IthimakinDivision of Medical Oncology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-4205-6112
Napa ParinyanitikulDepartment of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-3701-5663
Sung-Bae KimDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5588-8332
Yoon-Sim YapDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.ORCID https://orcid.org/0000-0002-0347-5066
Janice TsangDepartment of Medicine, and Medical Ethics & Humanities unit, The University of Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0002-2574-5987
Inda S SoongDepartment of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hospital Authority, Hong Kong.ORCID https://orcid.org/0000-0002-8911-8798
Yukinori OzakiDepartment of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8064-648X
Shinji OhnoBreast Oncology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2093-3353
Makiko OnoDepartment of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID https://orcid.org/0000-0002-3151-451X
Jack Junjie ChanDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.ORCID https://orcid.org/0000-0002-7214-8368
Hung Chun Skye ChengDepartment of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-5331-6688
Thitiya DejthevapornMedical Oncology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. tsirisinha@yahoo.com.ORCID https://orcid.org/0000-0003-1808-7303
BIG-Asia Collaboration
The Cancer Institute Hospital · JPNational Cancer Centre Singapore · SGCal Humanities · USChulalongkorn University · THHospital Authority · HKMahidol University · THNational Taitung University · TWSiriraj Hospital · THUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreast cancer (BC) treatment has shifted from chemotherapy to targeted therapy. Several targeted agents have demonstrated an improvement in survival. Given that national healthcare resources were correlated with the cancer mortality-to-incidence ratio, we compared access to BC drugs in Thailand with that in other Asian countries.

methodsBC experts involved in the Breast International Group (BIG)-Asia in six representative groups for countries or special administrative region (SAR) in Asia (Hong Kong SAR, Japan, Korea, Taiwan, Thailand, and Singapore) were invited to participate in the survey. The questionnaire addressed national health reimbursement schemes, molecular testing for early BC (EBC), availability and accessibility of BC drugs. Accessibility and reimbursement of the drugs were reported based on their listing as essential medicines in the World Health Organization Model List of Essential Medicines (WHO-EML) and their nomination as effective drugs in the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS). The study was approved by all participating BIG-Asia organizations in November 2021.

resultsGenomic tests for EBC were non-reimbursable in all surveyed territories. Reimbursement and co-payment of BC drugs vary between and within these regions (particularly Thailand). Most drugs in the WHO-EML and ESMO-MCBS (A/B for EBC and 4/5 for advanced BC) were accessible in all surveyed territories. However, the accessibility of effective but costly WHO-EML and ESMO-MCBS drugs was not uniform in Thailand. There was an evident disparity for individuals covered by the Thai Social Security/Universal Health Coverage schemes.

conclusionEssential BC drugs are generally accessible in selected BIG-Asia countries or SAR. There is a disparity in accessing high-cost drugs in Thailand compared with other Asian territories.

Indexed as

Antineoplastic AgentsAsiansBreast NeoplasmsHealthcare DisparityThailand

Identifiers

PMID35657002
PMCPMC9250880
OpenAlexW4282935682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.