Trial reportJournal of the American Heart Association2022
Neutrophil-to-Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries.
Trial report in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Baseline neutrophil-to-lymphocyte ratio and efficacy of SGLT2 inhibition with empagliflozin on cardiac remodelling.ESC heart failure · 2023Trial
- Early postoperative "grey zone" gradients following aortic valve replacement surgery: the clinical course and mechanical stress biomarker profile.Surgery today · 2026Observational
- Association of the CALLY Index With 30-Day Outcomes After Transcatheter Aortic Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Association between preoperative nutritional status and mortality in patients with type B aortic dissection undergoing thoracic endovascular aortic repair: a retrospective cohort study.Journal of thoracic disease · 2026Article
- HALP score adds prognostic information beyond STS for 2-year mortality after transcatheter aortic valve implantation: a two-center retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Prognostic value of the endothelial activation and stress index (EASIX) for in-hospital and overall mortality in patients undergoing transcatheter aortic valve implantation.BMC cardiovascular disorders · 2026Article
- The Value of HALP Score in Predicting Adverse In-Hospital Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.Diagnostics (Basel, Switzerland) · 2026Article
- The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Associations between blood cell-based inflammatory indices and their changes and mortality in patients undergoing transcatheter aortic valve replacement: a retrospective investigation with prospective multicenter cohort validation study.International journal of surgery (London, England) · 2025Article
- Association Between Neutrophil Percentage-to-Albumin Ratio and 2-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement.Anatolian journal of cardiology · 2025Article
- Neutrophil-to-lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum.European journal of heart failure · 2025Article
- Neutrophil-to-Lymphocyte Ratio as Potential Marker of Outcome After Standard EVAR.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Biomarkers of Inflammation and Association with Cardiovascular Magnetic Resonance Imaging for Risk Stratification and Outcome in Patients with Severe Aortic Stenosis.Journal of clinical medicine · 2025Article
- Association between inflammatory hematological ratios and aortic valve stenosis: a propensity-matched analysis.Frontiers in cardiovascular medicine · 2025Article
- Review
- Predictive Value of Monocyte-To-Lymphocyte Ratio in Differentiating Heart Failure with Reduced Ejection Fraction in Patients with Severe Aortic Stenosis-A Retrospective Analysis.Journal of clinical medicine · 2024Article
- The Prognostic Role of the Neutrophil-to-Lymphocytes Ratio in the Most Frequent Cardiovascular Diseases: An Update.Life (Basel, Switzerland) · 2024Review
- Association between uric acid and cardiac outcomes mediated by neutrophil-to-lymphocyte ratio in patients with left ventricular diastolic dysfunction and pulmonary hypertension.Scientific reports · 2024Article
- Effect of Neutrophil-to-Lymphocyte Ratio on Post-TAVR Mortality and Periprocedural Pulmonary Hypertension.Journal of interventional cardiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow-up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5-24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70-4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18-1.63;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.