Evidence map›Paper›PMID 35656899›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias

A Functional Assessment Tool to Distinguish Controls From Alzheimer's Disease in Lima, Peru.

Nilton Custodio, Rosa Montesinos, Diego Chambergo-Michilot, Eder Herrera-Perez, Maritza Pintado-Caipa, Wendy Seminario G, José Cuenca, Laura Mesía, Virgilio E Failoc-Rojas, Monica M Diaz

Open access · goldAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Intervention and Prevention of Dementia in the Greater Bay Area (GBA) of China.American journal of Alzheimer's disease and other dementias
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Nilton CustodioServicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú.ORCID 0000-0002-8025-3272
Rosa MontesinosUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Diego Chambergo-MichilotUniversidad Científica Del Sur, Lima, Perú.
Eder Herrera-PerezUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Maritza Pintado-CaipaServicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú.
Wendy Seminario GServicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú.ORCID 0000-0001-8827-5487
José CuencaUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Laura MesíaUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Virgilio E Failoc-RojasUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.ORCID 0000-0003-2992-9342
Monica M DiazDepartment of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-9663-5948
Instituto de Neurología Cognitiva · ARUniversidad Científica del Sur · PEUniversidad Privada San Juan Bautista · PEUniversidad San Ignacio de Loyola · PEUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · US

Funding

San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
Genetic and environmental risk factors in mestizos and indigenous populations of Peru: the role of Native component in Alzheimer's diseaseR56AG069118 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TOSTO, GIUSEPPE · 2020 to 2020
$1.1M
NIA NIH HHS P30 AG059299NIA NIH HHS R56 AG069118
6 · The paper itself

Abstract

backgroundThe Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer's disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD.

methodsA cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach's alpha) and validity were assessed.

resultsWe enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC: .996), and Cronbach's alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools.

conclusionsThe ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.

Indexed as

Alzheimer DiseaseActivities of Daily LivingAgedCross-Sectional StudiesHumansPeruReproducibility of Resultsalzheimer diseasedementianeurocognitive disordersperuvalidation study

Identifiers

PMID35656899
PMCPMC10581136
OpenAlexW4282932002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.