Evidence map›Paper›PMID 35656825›Full record

ArticleStroke2022

Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions.

Sanem A Aykan, Hongyu Xie, Yi Zheng, David Y Chung, Sreekanth Kura, James Han Lai, Taylan D Erdogan, Andreia Morais, Isra Tamim, Damla Yagmur and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Sanem A AykanNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0001-7335-5556
Hongyu XieNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0001-6386-8083
Yi ZhengNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).
David Y ChungNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0002-7149-5851
Sreekanth KuraNeurophotonics Center, Department of Biomedical Engineering, Boston University, MA (S.K., D.A.B.).
James Han LaiNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0002-8414-0398
Taylan D ErdoganNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).
Andreia MoraisNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0002-9351-2552
Isra TamimNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).ORCID 0000-0002-4098-1160
Damla YagmurORCID 0000-0001-7729-1983
Hidehiro IshikawaNeuroprotection Research Laboratory, Department of Radiology and Neurology (H.I., K.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.ORCID 0000-0002-3077-7262
Ken AraiNeuroprotection Research Laboratory, Department of Radiology and Neurology (H.I., K.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.
M Abbas YaseenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.A.B., M.A.Y., S.S.), Massachusetts General Hospital, Charlestown, MA.
David A BoasNeurophotonics Center, Department of Biomedical Engineering, Boston University, MA (S.K., D.A.B.).ORCID 0000-0002-6709-7711
Sava SakadzicAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (D.A.B., M.A.Y., S.S.), Massachusetts General Hospital, Charlestown, MA.ORCID 0000-0001-6318-1193
Cenk AyataNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.).
Massachusetts General Hospital · USAnna Needs Neuroblastoma Answers · USAthinoula A. Martinos Center for Biomedical Imaging · USNeoPhotonics (United States) · US

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingR01NS115401 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK, SAKADZIC, SAVA · 2020 to 2024
$3.5M
Two-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4M
Determinants of Functional Brain Connectivity After Subarachnoid HemorrhageK08NS112601 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, DAVID YOUNG · 2019 to 2023
$1.0M
NINDS NIH HHS K08 NS112601NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS091230NINDS NIH HHS R01 NS115401
6 · The paper itself

Abstract

backgroundSubcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on functional recovery after focal white matter injury.

methodsA focal corpus callosum lesion was induced by stereotactic injection of N

resultsResting-state interhemispheric functional connectivity significantly recovered between days 1 and 14 in the fasudil group (

conclusionsThese data show that delayed fasudil posttreatment improves functional outcomes after a focal subcortical white matter lesion in mice. Future work will aim to elucidate the mechanisms.

Indexed as

LeukoaraiosisWhite MatterAnimalsCorpus CallosumHumansMiceRecovery of Functionrho-Associated Kinasesrho-Associated Kinasescell differentiationfasudilleukoaraiosisoligodendrocyteoptical imaging

Identifiers

PMID35656825
PMCPMC9245195
OpenAlexW4281907233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.