ArticleEpilepsia2022
Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.
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Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Alterations in glymphatic system and brain morphology in patients with temporal lobe epilepsy.BMC medical imaging · 2026Article
- Bilateral cornu ammonis 3-dominant mechanism of visual working memory impairment in right temporal lobe epilepsy and hippocampal sclerosis.Brain communications · 2026Article
- Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy.Epilepsia open · 2025Review
- The use of automated and AI-driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia.Epilepsia · 2025Review
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
- Progressive brain atrophy and cortical reorganization related to surgery in temporal lobe epilepsy.Annals of clinical and translational neurology · 2025Article
- Longitudinal changes in hippocampal morphology before and after temporal lobe epilepsy surgery.Brain communications · 2025Article
- Association of Normative and Non-Normative Brain Networks With Cognitive Function in Patients With Temporal Lobe Epilepsy.Neurology · 2024Article
- Impaired interhemispheric synchrony and effective connectivity in right temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Identification of four biotypes in temporal lobe epilepsy via machine learning on brain images.Nature communications · 2024Article
- Data-driven modelling of neurodegenerative disease progression: thinking outside the black box.Nature reviews. Neuroscience · 2024Review
- Out of one, how many? Subtyping in epilepsy.Brain : a journal of neurology · 2023Article
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- sEBM: Scaling Event Based Models to Predict Disease Progression via Implicit Biomarker Selection and Clustering.Information processing in medical imaging : proceedings of the ... conference · 2023Article
- Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.Epilepsia · 2022Article
- The cumulative impact of seizures: the science underlying how seizures beget seizures.Frontiers in neurologyReview
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
77 authors at 20 institutions in 13 countries.
Seymour M LopezCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Leon M AksmanCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Neil P OxtobyCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Sjoerd B VosCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID 0000-0002-8502-4487
Jun RaoDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Erik KaestnerDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-3252-5365
Saud AlhusainiDepartment of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Marina AlvimDepartment of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.ORCID 0000-0002-6780-0761
Benjamin BenderDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-9358-5703
Neda BernasconiNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-8947-9518
Boris BernhardtMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-9256-6041
Leonardo BonilhaDepartment of Neurology, Emory University, Atlanta, USA.
Lorenzo CaciagliMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Benoit CaldairouNeuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Maria Eugenia CaligiuriNeuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.ORCID 0000-0002-2030-5552
Angels CalvetMagnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.
Fernando CendesDepartment of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.ORCID 0000-0001-9336-9568
Luis ConchaInstitute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico.ORCID 0000-0002-7842-3869
Estefania Conde-BlancoEpilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain.ORCID 0000-0001-7436-987X
Esmaeil Davoodi-BojdRadiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.
Christophe de BézenacDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID 0000-0002-2433-9776
Norman DelantyDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-3953-9842
Patricia M DesmondDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Orrin DevinskyNew York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0003-0044-4632
Martin DominFunctional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germany.
John S DuncanDepartment of Neurology, Emory University, Atlanta, USA.
Niels K FockeDepartment of Neurology, University Medical Center, Göttingen, Germany.ORCID 0000-0001-5486-6289
Sonya FoleyCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
Francesco FortunatoInstitute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.ORCID 0000-0001-8395-7809
Marian GalovicDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Antonio GambardellaNeuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.ORCID 0000-0001-7384-3074
Ezequiel GleichgerrchtDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-4212-4146
Renzo GuerriniNeuroscience Department, University of Florence, Florence, Italy.ORCID 0000-0002-7272-7079
Khalid HamandiCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
Victoria Ives-DeliperiNeuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2640-249X
Graeme D JacksonFlorey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australia.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID 0000-0001-5247-9795
Peter KochunovDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Raviteja KotikalapudiDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Barbara A K KreilkampInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Angelo LabateNeuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.ORCID 0000-0002-8827-7324
Sara LarivièreMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-5701-1307
Matteo LengePediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Florence, Italy.
Elaine LuiDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Charles MalpasDepartment of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.ORCID 0000-0003-0534-3718
Pascal MartinDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mario MascalchiMario Serio Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stefano MelettiDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0003-0334-539X
Marcia E Morita-ShermanDepartment of Neurology, University of Campinas, Campinas, Brazil.ORCID 0000-0002-8531-3916
Thomas W OwenSchool of Computing, Newcastle University, Newcastle Upon Tyne, UK.
Mark RichardsonDivision of Neuroscience, King's College London, London, UK.
Antonella RivaGiannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy.ORCID 0000-0001-9152-5571
Theodor RüberDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-6180-7671
Ben SinclairDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-0850-3644
Hamid Soltanian-ZadehRadiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.
Dan J SteinSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Pasquale StrianoGiannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy.ORCID 0000-0002-6065-1476
Peter N TaylorDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0003-2144-9838
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Manuela TondelliDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0001-6698-5437
Anna Elisabetta VaudanoDepartment of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-6280-7526
Lucy VivashDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-1182-0907
Yujiang WangDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
Christopher D WhelanDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Roland WiestSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gavin P WinstonDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0001-9395-1478
Clarissa Lin YasudaDepartment of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
Carrie R McDonaldDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Daniel C AlexanderCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-1511-5893
Andre AltmannCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID 0000-0002-9265-2393
ENIGMA-Epilepsy Working Group
Montreal Neurological Institute and Hospital · CAThe Royal Melbourne Hospital · AUMagna Graecia University · ITNational Hospital for Neurology and Neurosurgery · GBUniversity College London · GBUniversity of Southern California · USRoyal College of Surgeons in Ireland · IEUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of California San Diego · USUniversity of Liverpool · GBUniversity of Modena and Reggio Emilia · ITEmory University · USHenry Ford Health System · USIstituto Giannina Gaslini · ITUniversity of Florence · ITUniversity of Maryland, Baltimore · USAutonomous University of Queretaro · MXBiomedical Research Institute · USCardiff University · GBCleveland Clinic · US
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MFellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MMultimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4MBRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigationof vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyR01NS120976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$4.1MLifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MHigh resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MA global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5MRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kDepartment of HealthMedical Research Council G0802012Medical Research Council MR/K013998/1Medical Research Council MR/K023152/1Medical Research Council MR/L016311/1Medical Research Council MR/M00841X/1Medical Research Council MR/N026063/1Medical Research Council MR/S00355X/1Medical Research Council MR/S03546X/1Medical Research Council MR/T04294X/1NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG059874NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB015611NIH HHS S10 OD023696NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS RF1 MH123163NIMH NIH HHS T32 MH018399NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS120976NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739
Abstract
objectiveRecent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features.
methodsWe extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance.
resultsIn MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10 SIGNIFICANCE: From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.
Indexed as
EpilepsyEpilepsy, Temporal LobeAtrophyBiomarkersCross-Sectional StudiesHippocampusHumansMagnetic Resonance ImagingSclerosisBiomarkersdisease progressionduration of illnessevent-based modelMTLEpatient staging
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